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Database Commons - DetoxiProt

DetoxiProt

Citations: 3

z-index 0.26

Short name DetoxiProt
Full name An integrated database of detoxification proteins
Description DetoxiProt is an integrated database aims to provide a useful and comprehensive gene resource for detoxification proteins or toxin metabolizing enzymes.
URL http://lifecenter.sgst.cn/detoxiprot/
Year founded 2010
Last update & version 2010-02-25    V1.0
Availability Free to all users
University/Institution hosted Fudan University
Address School of Life Science, Fudan University, HanDan Road 220#, Shanghai, 200433, China.
City Shanghai
Province/State
Country/Region China
Contact name Yang Zhong
Contact email yangzhong@fudan.edu.cn
Data type(s)
Major organism(s)
Keyword(s)
  • toxin metabolizing
  • toxin metabolizing enzymes
Publication(s)
  • DetoxiProt: an integrated database for detoxification proteins. [PMID: 22369658]

    Zhen Yang, Ying Yu, Lei Yao, Guangui Li, Lin Wang, Yiyao Hu, Haibin Wei, Li Wang, Riadh Hammami, Roxanne Razavi, Yang Zhong, Xufang Liang
    BMC genomics 2011:12 Suppl 3
    3 Citations (Google Scholar as of 2016-01-13)

    Abstract: Detoxification proteins are a class of proteins for degradation and/or elimination of endogenous and exogenous toxins or medicines, as well as reactive oxygen species (ROS) produced by these materials. Most of these proteins are generated as a response to the stimulation of toxins or medicines. They are essential for the clearance of harmful substances and for maintenance of physiological balance in organisms. Thus, it is important to collect and integrate information on detoxification proteins. To store, retrieve and analyze the information related to their features and functions, we developed the DetoxiProt, a comprehensive database for annotation of these proteins. This database provides detailed introductions about different classes of the detoxification proteins. Extensive annotations of these proteins, including sequences, structures, features, inducers, inhibitors, substrates, chromosomal location, functional domains as well as physiological-biochemical properties were generated. Furthermore, pre-computed BLAST results, multiple sequence alignments and evolutionary trees for detoxification proteins are also provided for evolutionary study of conserved function and pathways. The current version of DetoxiProt contains 5956 protein entries distributed in 628 organisms. An easy to use web interface was designed, so that annotations about each detoxification protein can be retrieved by browsing with a specific method or by searching with different criteria. DetoxiProt provides an effective and efficient way of accessing the detoxification protein sequences and other high-quality information. This database would be a valuable source for toxicologists, pharmacologists and medicinal chemists. DetoxiProt database is freely available at http://lifecenter.sgst.cn/detoxiprot/.

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Tags

Drug and Chemical Compound Protein
Acyrthosiphon pisum Caenorhabditis elegans Danio rerio Drosophila melanogaster Gallus gallus Homo sapiens Mus musculus Pan troglodytes Rattus norvegicus
toxin metabolizing toxin metabolizing enzymes

Record metadata

  • Created on: 2015-06-30
  • Curated by:
    • Jian Sang [2016-04-04]
    • Mengwei Li [2016-02-20]
    • Jian Sang [2015-12-07]
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