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Database Commons - CORG

CORG

Citations: 84

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Short name CORG
Full name Comparative Regulatory Genomics
Description The CORG resource provides extensive cross-species comparisons of promoter regions in particular and whole gene loci in general.
URL http://corg.eb.tuebingen.mpg.de
Year founded 2003
Last update & version     
Availability Not Available
University/Institution hosted Max Planck Institute for Developmental Biology Spemannstrasse
Address 35-37, 72076 Tübingen, Germany
City Tübingen
Province/State
Country/Region Germany
Contact name C. Dieterich
Contact email christoph.dieterich@tuebingen.mpg.de
Data type(s)
Major organism(s)
Keyword(s)
  • cross-species comparison
  • ncRNA
Publication(s)
  • Developments in CORG: a gene-centric comparative genomics resource. [PMID: 17135197]

    C Dieterich, M W Franz, M Vingron
    Nucleic acids research 2007:35(Database issue)
    1 Citations (Google Scholar as of 2016-01-27)

    Abstract: The CORG resource (Comparative Regulatory Genomics, http://corg.eb.tuebingen.mpg.de) provides extensive cross-species comparisons of promoter regions in particular and whole gene loci in general. Pairwise as well as multiple alignments of 10 vertebrate species form the key component of CORG. We implemented a rapid alignment approach based on weight matrix motif anchors to ensure efficient computation and biologically informative alignments. All CORG workbench components have been enhanced towards more flexibility and interactivity. Reference sequence based data presentation and analysis was put into the well-known and modular Generic Genome Browser framework. Herein, various plugins facilitate online data analysis and integration with static conservation data. Main emphasis was put on the design of a new JAVA WebStart application for comparative data display. Flexible data import and export options for standard formats complete the provided services.

  • CORG: a database for COmparative Regulatory Genomics. [PMID: 12519946]

    C Dieterich, H Wang, K Rateitschak, H Luz, M Vingron
    Nucleic acids research 2003:31(1)
    83 Citations (Google Scholar as of 2016-01-27)

    Abstract: Sequence conservation in non-coding, upstream regions of orthologous genes from man and mouse is likely to reflect common regulatory DNA sites. Motivated by this assumption we have delineated a catalogue of conserved non-coding sequence blocks and provide the CORG-'COmparative Regulatory Genomics'-database. The data were computed based on statistically significant local suboptimal alignments of 15 kb regions upstream of the translation start sites of, currently, 10 793 pairs of orthologous genes. The resulting conserved non-coding blocks were annotated with EST matches for easier detection of non-coding mRNA and with hits to known transcription factor binding sites. CORG data are accessible from the ENSEMBL web site via a DAS service as well as a specially developed web service (http://corg.molgen.mpg.de) for query and interactive visualization of the conserved blocks and their annotation.

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Tags

DNA
Homo sapiens Mus musculus
cross-species comparison ncRNA

Record metadata

  • Created on: 2015-07-13
  • Curated by:
    • Mengwei Li [2016-03-31]
    • Mengwei Li [2015-12-05]
    • Jian Sang [2015-07-13]
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