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Database Commons - HRTBLDb

HRTBLDb

Citations: 9

z-index 0.00

Short name HRTBLDb
Full name Hormone Receptors Target Binding Loci Database
Description The HRTBLDb is a collection of estrogen, androgen, and glucocorticoid receptor binding site data.
URL http://motif.bmi.ohio-state.edu/hrtbldb/
Year founded 2010
Last update & version 2009-09-22    v1.0
Availability Free to all users
University/Institution hosted The Ohio State University
Address Columbus, OH 43210, USA
City Columbus
Province/State OH
Country/Region United States
Contact name Victor X. Jin
Contact email victor.jin@osumc.edu
Data type(s)
Major organism(s)
Keyword(s)
  • estrogen, androgen, and glucocorticoid
  • receptor binding site
Publication(s)
  • HRTBLDb: an informative data resource for hormone receptors target binding loci. [PMID: 19773424]

    Brian A Kennedy, Wenqing Gao, Tim H-M Huang, Victor X Jin
    Nucleic acids research 2010:38(Database issue)
    9 Citations (Google Scholar as of 2016-04-27)

    Abstract: Three hormone receptors, the estrogen receptor (ER), the androgen receptor (AR) and glucocorticoid receptor (GR) play an important role in regulating the cellular differentiation tissue development of skin, bone, the brain and the endocrine system; therefore, there is a strong scientific need to identify and characterize hormone receptor transcriptional regulation. Given that the vast amount of regulatory data for hormone being produced by ChIP-based high-throughput experiments is widely scattered in disparate, poorly cross-indexed data stores, a flexible platform for organizing and relating these data would provide significant value. We created a data management system called the Hormone Receptor Target Binding Loci, HRTBLDb (http://motif.bmi.ohio-state.edu/hrtbldb), to address this problem. This database contains hormone receptor binding regions (binding loci) from in vivo ChIP-based high-throughput experiments as well as in silico, computationally predicted, binding motifs and cis-regulatory modules for the co-occurring transcription factor binding motifs, which are within a binding locus. It also contains individual binding sites whose regulatory action has been verified by in vitro experiments. The current version contains 44,673 binding elements with 114 hormone response elements which are verified by in vitro experiments; 75 binding motifs which occur with a hormone response element and whose co-regulatory action is verified by in vitro experiments; 18,472 binding loci from in vivo experiments; and 26,012 computationally predicted binding motifs.

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Tags

Protein
Homo sapiens Mus musculus
estrogen, androgen, and glucocorticoid receptor binding site

Record metadata

  • Created on: 2015-07-16
  • Curated by:
    • Chunlei Yu [2016-03-31]
    • Chunlei Yu [2015-11-19]
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