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Database Commons - Dr.VIS

Dr.VIS

Citations: 14

z-index 1.17

Short name Dr.VIS
Full name Viral integration sites
Description Dr.VIS collects and locates human disease-related viral integration sites. So far, about 600 sites covering 5 virus organisms and 11 human diseases are available.
URL http://www.bioinfo.org/drvis/
Year founded 2012
Last update & version 6/30/2014    v2.0
Availability Free to all users
University/Institution hosted Chinese Academy of Medical Sciences and Peking Union Medical College
Address Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC),Beijing,China
City Beijing
Province/State
Country/Region China
Contact name Haitao Zhao
Contact email zhaoht@pumch.cn
Data type(s)
Major organism(s)
Keyword(s)
  • disease
  • viral integration sites
Publication(s)
  • Dr.VIS v2.0: an updated database of human disease-related viral integration sites in the era of high-throughput deep sequencing. [PMID: 25355513]

    Xiaobo Yang, Ming Li, Qi Liu, Yabing Zhang, Junyan Qian, Xueshuai Wan, Anqiang Wang, Haohai Zhang, Chengpei Zhu, Xin Lu, Yilei Mao, Xinting Sang, Haitao Zhao, Yi Zhao, Xiaoyan Zhang
    Nucleic acids research 2015:43(Database issue)
    1 Citations (Google Scholar as of 2016-04-07)

    Abstract: Dr.VIS is a database of human disease-related viral integration sites (VIS). The number of VIS has grown rapidly since Dr.VIS was first released in 2011, and there is growing recognition of the important role that viral integration plays in the development of malignancies. The updated database version, Dr.VIS v2.0 (http://www.bioinfo.org/drvis or bminfor.tongji.edu.cn/drvis_v2), represents 25 diseases, covers 3340 integration sites of eight oncogenic viruses in human chromosomes and provides more accurate information about VIS from high-throughput deep sequencing results obtained mainly after 2012. Data of VISes for three newly identified oncogenic viruses for 14 related diseases have been added to this 2015 update, which has a 5-fold increase of VISes compared to Dr.VIS v1.0. Dr.VIS v2.0 has 2244 precise integration sites, 867 integration regions and 551 junction sequences. A total of 2295 integration sites are located near 1730 involved genes. Of the VISes, 1153 are detected in the exons or introns of genes, with 294 located up to 5 kb and a further 112 located up to 10 kb away. As viral integration may alter chromosome stability and gene expression levels, characterizing VISes will contribute toward the discovery of novel oncogenes, tumor suppressor genes and tumor-associated pathways. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  • Dr.VIS: a database of human disease-related viral integration sites. [PMID: 22135288]

    Xin Zhao, Qi Liu, Qingqing Cai, Yanyun Li, Congjian Xu, Yixue Li, Zuofeng Li, Xiaoyan Zhang
    Nucleic acids research 2012:40(Database issue)
    13 Citations (Google Scholar as of 2016-04-07)

    Abstract: Viral integration plays an important role in the development of malignant diseases. Viruses differ in preferred integration site and flanking sequence. Viral integration sites (VIS) have been found next to oncogenes and common fragile sites. Understanding the typical DNA features near VIS is useful for the identification of potential oncogenes, prediction of malignant disease development and assessing the probability of malignant transformation in gene therapy. Therefore, we have built a database of human disease-related VIS (Dr.VIS, http://www.scbit.org/dbmi/drvis) to collect and maintain human disease-related VIS data, including characteristics of the malignant disease, chromosome region, genomic position and viral-host junction sequence. The current build of Dr.VIS covers about 600 natural VIS of 5 oncogenic viruses representing 11 diseases. Among them, about 200 VIS have viral-host junction sequence.

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200 OK2016-01-15
200 OK2016-01-13
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200 OK2016-01-10
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200 OK2016-01-04

Tags

Disease DNA
Homo sapiens
disease viral integration sites

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Lina Ma [2016-04-07]
    • Jian Sang [2016-04-04]
    • Jian Sang [2015-06-27]
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