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Database Commons - The imprinted gene and parent-of-origin effect database

The imprinted gene and parent-of-origin effect database

Citations: 551

z-index 19.01

Short name The imprinted gene and parent-of-origin effect database
Full name
Description The imprinted gene and parent-of-origin effect database (www.otago.ac.nz/IGC) consists of two sections. One section catalogues the current literature on imprinted genes in humans and animals. The second, and new, section catalogues current reports of parental origin of de novo mutations in humans alone.
URL http://www.otago.ac.nz/IGC
Year founded 1998
Last update & version 2006-01-01    1.0
Availability Free to all users
University/Institution hosted University of Otago
Address Department of Microbiology, University of Otago PO Box 56, Dunedin, New Zealand
City Dunedin
Province/State
Country/Region New Zealand
Contact name Rivka L. Glaser
Contact email rglaser@mcla.edu
Data type(s)
Major organism(s)
Keyword(s)
  • imprinted gene
  • spontaneous mutation
Publication(s)
  • The imprinted gene and parent-of-origin effect database now includes parental origin of de novo mutations. [PMID: 16381868]

    Rivka L Glaser, Joshua P Ramsay, Ian M Morison
    Nucleic acids research 2006:34(Database issue)
    80 Citations (Google Scholar as of 2016-04-29)

    Abstract: The imprinted gene and parent-of-origin effect database (www.otago.ac.nz/IGC) consists of two sections. One section catalogues the current literature on imprinted genes in humans and animals. The second, and new, section catalogues current reports of parental origin of de novo mutations in humans alone. The addition of a catalogue of de novo mutations that show a parent-of-origin effect expands the scope of the database and provides a useful tool for examining parental origin trends for different types of spontaneous mutations. This new section includes >1700 mutations, found in 59 different disorders. The 85 imprinted genes are described in 152 entries from several mammalian species. In addition, >300 other entries describe a range of reported parent-of-origin effects in animals.

  • The imprinted gene and parent-of-origin effect database. [PMID: 11125110]

    I M Morison, C J Paton, S D Cleverley
    Nucleic acids research 2001:29(1)
    226 Citations (Google Scholar as of 2016-04-29)

    Abstract: The database of imprinted genes and parent-of-origin effects in animals (http://www.otago.ac.nz/IGC ) is a collation of genes and phenotypes for which parent-of-origin effects have been reported. The database currently includes over 220 entries, which describe over 40 imprinted genes in human, mouse and other animals. In addition a wide variety of other parent-of-origin effects, such as transmission of human disease phenotypes, transmission of QTLs, uniparental disomies and interspecies crosses are recorded. Data are accessed through a search engine and references are hyperlinked to PubMed.

  • A catalogue of imprinted genes and parent-of-origin effects in humans and animals. [PMID: 9735381]

    I M Morison, A E Reeve
    Human molecular genetics 1998:7(10)
    245 Citations (Google Scholar as of 2016-04-29)

    Abstract: Parent-of-origin effects were first recorded >3000 years ago by mule breeders in Asia Minor. There are now several different types of evidence suggesting the presence of a large number of imprinted genes, many of which have not yet been identified. Here, we catalogue a wide range of evidence and phenomena which indicate or suggest the presence of genomic imprinting in animals. This evidence includes: the direct documentation of parent-of-origin-specific gene transcription; human disease inheritance patterns which suggest the involvement of imprinted genes; and older, less well studied animal models which may show parent-of-origin effects.

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200 OK2016-02-22
200 OK2016-02-19
200 OK2016-02-17
200 OK2016-02-15
200 OK2016-02-14
200 OK2016-02-12
200 OK2016-02-10
200 OK2016-02-08
200 OK2016-02-07
200 OK2016-02-05
200 OK2016-02-03
200 OK2016-02-01
200 OK2016-01-31
200 OK2016-01-29
200 OK2016-01-27
200 OK2016-01-25
200 OK2016-01-24
200 OK2016-01-22
200 OK2016-01-20
200 OK2016-01-18
200 OK2016-01-17
-1 Failed2016-01-15
200 OK2016-01-13
200 OK2016-01-11
200 OK2016-01-10
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Tags

Literature Phenotype
Homo sapiens Mus musculus
imprinted gene spontaneous mutation

Record metadata

  • Created on: 2015-07-17
  • Curated by:
    • Guangyu Wang [2016-04-01]
    • Mengwei Li [2016-02-16]
    • Lina Ma [2015-12-31]
    • Guangyu Wang [2015-12-06]
Stats