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Database Commons - NOPdb

NOPdb

Citations: 96

z-index 0.00

Short name NOPdb
Full name Nucleolar Proteome Database
Description Nucleolar Proteome Database contains all of the data from our ongoing proteomic analysis of human nucleoli, which is carried out as a collaboration between the Lamond and Mann laboratories (in Denmark and Munich).
URL http://www.lamondlab.com/NOPdb/
Year founded 2004
Last update & version 2006-09-21    2.0
Availability Free to all users
University/Institution hosted University of Dundee
Address Dundee DD1 5EH, UK.
City Dundee
Province/State
Country/Region United Kingdom
Contact name Leung AK
Contact email akleung@mit.edu
Data type(s)
Major organism(s)
Keyword(s)
  • proteome
Publication(s)
  • NOPdb: Nucleolar Proteome Database. [PMID: 16381850]

    Anthony Kar Lun Leung, Laura Trinkle-Mulcahy, Yun Wah Lam, Jens S Andersen, Matthias Mann, Angus I Lamond
    Nucleic acids research 2006:34(Database issue)
    96 Citations (Google Scholar as of 2016-05-05)

    Abstract: The Nucleolar Proteome Database (NOPdb) archives data on >700 proteins that were identified by multiple mass spectrometry (MS) analyses from highly purified preparations of human nucleoli, the most prominent nuclear organelle. Each protein entry is annotated with information about its corresponding gene, its domain structures and relevant protein homologues across species, as well as documenting its MS identification history including all the peptides sequenced by tandem MS/MS. Moreover, data showing the quantitative changes in the relative levels of approximately 500 nucleolar proteins are compared at different timepoints upon transcriptional inhibition. Correlating changes in protein abundance at multiple timepoints, highlighted by visualization means in the NOPdb, provides clues regarding the potential interactions and relationships between nucleolar proteins and thereby suggests putative functions for factors within the 30% of the proteome which comprises novel/uncharacterized proteins. The NOPdb (http://www.lamondlab.com/NOPdb) is searchable by either gene names, nucleotide or protein sequences, Gene Ontology terms or motifs, or by limiting the range for isoelectric points and/or molecular weights and links to other databases (e.g. LocusLink, OMIM and PubMed).

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Tags

Protein
Homo sapiens
proteome

Record metadata

  • Created on: 2015-07-18
  • Curated by:
    • Lin Liu [2016-03-28]
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