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Database Commons - Open TG-GATEs

Open TG-GATEs

Citations: 17

z-index 0.00

Short name Open TG-GATEs
Full name Toxicogenomics Project-Genomics Assisted Toxicity Evaluation System
Description Gathered data on gene expression and toxicity in rats and the primary cultured hepatocytes of rats and humans following exposure to 150 compounds (pharmaceutical products, etc.), and used this data to build a large-scale, high-quality toxicogenomics database.
URL http://toxico.nibio.go.jp/english/index.html
Year founded 2008
Last update & version 2014-10-13    v1.0
Availability Free to all users
University/Institution hosted National Institute of Biomedical Innovation
Address Osaka 567-0085,Japan
City Osaka
Province/State
Country/Region Japan
Contact name Hiroshi Yamada
Contact email h-yamada@nibio.go.jp
Data type(s)
Major organism(s)
Keyword(s)
  • toxicogenomics
Publication(s)
  • Open TG-GATEs: a large-scale toxicogenomics database. [PMID: 25313160]

    Yoshinobu Igarashi, Noriyuki Nakatsu, Tomoya Yamashita, Atsushi Ono, Yasuo Ohno, Tetsuro Urushidani, Hiroshi Yamada
    Nucleic acids research 2015:43(Database issue)
    17 Citations (Google Scholar as of 2016-03-28)

    Abstract: Toxicogenomics focuses on assessing the safety of compounds using gene expression profiles. Gene expression signatures from large toxicogenomics databases are expected to perform better than small databases in identifying biomarkers for the prediction and evaluation of drug safety based on a compound's toxicological mechanisms in animal target organs. Over the past 10 years, the Japanese Toxicogenomics Project consortium (TGP) has been developing a large-scale toxicogenomics database consisting of data from 170 compounds (mostly drugs) with the aim of improving and enhancing drug safety assessment. Most of the data generated by the project (e.g. gene expression, pathology, lot number) are freely available to the public via Open TG-GATEs (Toxicogenomics Project-Genomics Assisted Toxicity Evaluation System). Here, we provide a comprehensive overview of the database, including both gene expression data and metadata, with a description of experimental conditions and procedures used to generate the database. Open TG-GATEs is available from http://toxico.nibio.go.jp/english/index.html. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

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Tags

Expression Metadata
Homo sapiens Rattus norvegicus
toxicogenomics

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Lin Liu [2016-03-28]
    • Li Yang [2015-06-26]
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