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Database Commons - ExDom

ExDom

Citations: 10

z-index 0.23

Short name ExDom
Full name ExDom
Description ExDom is an integrated database for comparative analysis of the exon–intron structures of protein domains in eukaryotes.
URL http://66.170.16.154/ExDom/
Year founded 2009
Last update & version     v1.0
Availability Free to all users
University/Institution hosted Genome International Corp
Address Department of Human Genetics, Genome International Corp, 8000 Excelsior Drive, Madison, WI 53717, USA
City Madison
Province/State WI
Country/Region United States
Contact name Periannan Senapathy
Contact email ps@genome.com
Data type(s)
Major organism(s)
Keyword(s)
  • exon–intron structure
  • protein domain
Publication(s)
  • ExDom: an integrated database for comparative analysis of the exon-intron structures of protein domains in eukaryotes. [PMID: 18984624]

    Ashwini Bhasi, Philge Philip, Vinu Manikandan, Periannan Senapathy
    Nucleic acids research 2009:37(Database issue)
    10 Citations (Google Scholar as of 2016-01-26)

    Abstract: We have developed ExDom, a unique database for the comparative analysis of the exon-intron structures of 96 680 protein domains from seven eukaryotic organisms (Homo sapiens, Mus musculus, Bos taurus, Rattus norvegicus, Danio rerio, Gallus gallus and Arabidopsis thaliana). ExDom provides integrated access to exon-domain data through a sophisticated web interface which has the following analytical capabilities: (i) intergenomic and intragenomic comparative analysis of exon-intron structure of domains; (ii) color-coded graphical display of the domain architecture of proteins correlated with their corresponding exon-intron structures; (iii) graphical analysis of multiple sequence alignments of amino acid and coding nucleotide sequences of homologous protein domains from seven organisms; (iv) comparative graphical display of exon distributions within the tertiary structures of protein domains; and (v) visualization of exon-intron structures of alternative transcripts of a gene correlated to variations in the domain architecture of corresponding protein isoforms. These novel analytical features are highly suited for detailed investigations on the exon-intron structure of domains and make ExDom a powerful tool for exploring several key questions concerning the function, origin and evolution of genes and proteins. ExDom database is freely accessible at: http://66.170.16.154/ExDom/.

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Tags

Protein Structure
Arabidopsis thaliana Bos taurus Danio rerio Gallus gallus Homo sapiens Mus musculus Rattus norvegicus
exon–intron structure protein domain

Record metadata

  • Created on: 2015-07-27
  • Curated by:
    • Jian Sang [2016-04-05]
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