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Database Commons - PharmGKB

PharmGKB

Citations: 67

z-index 1.34

Short name PharmGKB
Full name The Pharmacogenomics Knowledgebase
Description PharmGKB is a knowledge base that captures the relationships between drugs, diseases/phenotypes and genes involved in pharmacokinetics (PK) and pharmacodynamics (PD).
URL https://www.pharmgkb.org/
Year founded 2008
Last update & version 2008-01-01    v1.0
Availability Free to all users
University/Institution hosted Stanford University
Address
City Stanford
Province/State California
Country/Region United States
Contact name Teri E. Klein
Contact email teri.klein@stanford.edu
Data type(s)
Major organism(s)
Keyword(s)
  • pharmacodynamics
  • pharmacokinetics
Publication(s)
  • The pharmacogenetics and pharmacogenomics knowledge base: accentuating the knowledge. [PMID: 18032438]

    Tina Hernandez-Boussard, Michelle Whirl-Carrillo, Joan M Hebert, Li Gong, Ryan Owen, Mei Gong, Winston Gor, Feng Liu, Chuong Truong, Ryan Whaley, Mark Woon, Tina Zhou, Russ B Altman, Teri E Klein
    Nucleic acids research 2008:36(Database issue)
    67 Citations (Google Scholar as of 2016-02-29)

    Abstract: PharmGKB is a knowledge base that captures the relationships between drugs, diseases/phenotypes and genes involved in pharmacokinetics (PK) and pharmacodynamics (PD). This information includes literature annotations, primary data sets, PK and PD pathways, and expert-generated summaries of PK/PD relationships between drugs, diseases/phenotypes and genes. PharmGKB's website is designed to effectively disseminate knowledge to meet the needs of our users. PharmGKB currently has literature annotations documenting the relationship of over 500 drugs, 450 diseases and 600 variant genes. In order to meet the needs of whole genome studies, PharmGKB has added new functionalities, including browsing the variant display by chromosome and cytogenetic locations, allowing the user to view variants not located within a gene. We have developed new infrastructure for handling whole genome data, including increased methods for quality control and tools for comparison across other data sources, such as dbSNP, JSNP and HapMap data. PharmGKB has also added functionality to accept, store, display and query high throughput SNP array data. These changes allow us to capture more structured information on phenotypes for better cataloging and comparison of data. PharmGKB is available at www.pharmgkb.org.

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Tags

Disease DNA Drug and Chemical Compound Phenotype
Homo sapiens
pharmacodynamics pharmacokinetics

Record metadata

  • Created on: 2015-07-28
  • Curated by:
    • Zhang Zhang [2016-04-26]
    • Shixiang Sun [2016-03-25]
    • Mengwei Li [2016-02-20]
    • Shixiang Sun [2015-11-21]
    • Shixiang Sun [2015-11-20]
Stats