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Database Commons - Greglist

Greglist

Citations: 43

z-index 2.75

Short name Greglist
Full name Database of G-quadruplex Regulated Genes
Description Greglist is a database listing potential G-quadruplex regulated genes.
URL http://tubic.tju.edu.cn/greglist/
Year founded 2007
Last update & version 2007-10-19    
Availability Free to all users
University/Institution hosted Tianjin Cancer Institute and Hospital
Address Tianjin 300060, China
City Tianjin
Province/State Tianjin
Country/Region China
Contact name Chun-Ting Zhang
Contact email ctzhang@tju.edu.cn
Data type(s)
Major organism(s)
Keyword(s)
  • G-quadruplex regulated gene
Publication(s)
  • Greglist: a database listing potential G-quadruplex regulated genes. [PMID: 17916572]

    Ren Zhang, Yan Lin, Chun-Ting Zhang
    Nucleic acids research 2008:36(Database issue)
    43 Citations (Google Scholar as of 2016-04-28)

    Abstract: The double helix is a conformation that genomic DNA usually assumes; under certain conditions, however, guanine-rich DNA sequences can form a four-stranded structure, G-quadruplex, which is found to play a role in regulating gene expression. Indeed, it has been demonstrated that the G-quadruplex formed in the c-MYC promoter suppresses its transcriptional activity. Recent studies suggest that G-quadruplex motifs (GQMs) are enriched in human gene promoters. To facilitate the research of G-quadruplex, we have constructed Greglist, a database listing potentially G-quadruplex regulated genes. Greglist harbors genes that contain promoter GQMs from genomes of various species, including humans, mice, rats and chickens. Many important genes are found to contain previously unreported promoter GQMs, such as ATM, BAD, AKT1, LEPR, UCP1, APOE, DKK1, WT1, WEE1, WNT1 and CLOCK. Furthermore, we find that not only protein coding genes, 126 human microRNAs also contain promoter GQMs. Greglist therefore provides candidates for further studying G-quadruplex functions and is freely available at http://tubic.tju.edu.cn/greglist.

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Tags

DNA Protein
Aedes aegypti Caenorhabditis elegans Ciona intestinalis Dasypus novemcinctus Felis catus Gallus gallus Homo sapiens Mus musculus Rattus norvegicus
G-quadruplex regulated gene

Record metadata

  • Created on: 2015-07-29
  • Curated by:
    • Lin Liu [2016-03-29]
    • Mengwei Li [2016-02-20]
    • Jian Sang [2015-12-05]
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