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Database Commons - HPtaa database

HPtaa database

Citations: 18

z-index 0.50

Short name HPtaa database
Full name
Description HPtaa database provides potential target genes for clinical diagnosis and immunotherapy of human carcinoma.
URL http://www.hptaa.org
Year founded 2006
Last update & version 2006-01-01    v1.0
Availability Not Available
University/Institution hosted Peking University
Address Peking University Health Science Center Beijing 100083, China
City Beijing
Province/State
Country/Region China
Contact name Weifeng Chen
Contact email wfchen@public.bta.net.cn
Data type(s)
Major organism(s)
Keyword(s)
  • tumor-associated antigen
Publication(s)
  • HPtaa database-potential target genes for clinical diagnosis and immunotherapy of human carcinoma. [PMID: 16381942]

    Xiaosong Wang, Haitao Zhao, Qingwen Xu, Weibo Jin, Changning Liu, Huagang Zhang, Zhibin Huang, Xinyu Zhang, Yu Zhang, Dianqi Xin, Andrew J G Simpson, Lloyd J Old, Yanqun Na, Yi Zhao, Weifeng Chen
    Nucleic acids research 2006:34(Database issue)
    18 Citations (Google Scholar as of 2016-01-25)

    Abstract: Tumor-associated antigens (TAAs) have been the most actively employed targets in the clinical diagnosis and treatment of human carcinoma, such as PSA in the diagnosis of prostate cancer and NY-ESO-1 in the immunotherapy of melanoma and other cancers. However, identification of TAAs has often been hampered by the complicated and laborsome laboratory procedures. In order to accelerate the process of tumor antigen discovery, and thereby improve diagnosis and treatment of human carcinoma, we have made an effort to establish a publicly available Human Potential Tumor Associated Antigen database (HPtaa) with potential TAAs identified by in silico computing (http://www.hptaa.org). Tumor specificity was chosen as the core of tumor antigen evaluation, together with other relevant clues. Various platforms of gene expression, including microarray, expressed sequence tag and SAGE data, were processed and integrated by several penalty algorithms. A total of 3518 potential TAAs have been included in the database, which is freely available to academic users. As far as we know, this database is the first one addressing human potential TAAs, and the first one integrating various kinds of expression platforms for one purpose.

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Tags

DNA
Homo sapiens
tumor-associated antigen

Record metadata

  • Created on: 2015-09-09
  • Curated by:
    • Chunlei Yu [2016-04-17]
    • Chunlei Yu [2016-03-31]
    • Mengwei Li [2016-02-21]
    • Chunlei Yu [2015-11-19]
Stats