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Database Commons - SEA

SEA

Citations: 1

z-index 0.50

Short name SEA
Full name Super-Enhancer Archive
Description Super-Enhancer Archive is a web based comprehensive resource focuses on the collection, storage and online analysis of super-enhancers. Our mission is to provide a curated set of information datasets for super-enhancers and tools in mutiple genomes, to support and promote research in this area. Especially, we provide a genome-scale landscape to show super-enhancer information in a scalable and flexible manner.
URL http://sea.edbc.org
Year founded 2015
Last update & version 2015-10-25    v1.0
Availability Free to academic users only
University/Institution hosted Harbin Medical University
Address Harbin 150081, China
City Harbin
Province/State Heilongjiang
Country/Region China
Contact name Yan Zhang
Contact email tyozhang@ems.hrbmu.edu.cn
Data type(s)
Major organism(s)
Keyword(s)
  • gene expression
  • super-enhancer
Publication(s)
  • SEA: a super-enhancer archive. [PMID: 26578594]

    Yanjun Wei, Shumei Zhang, Shipeng Shang, Bin Zhang, Song Li, Xinyu Wang, Fang Wang, Jianzhong Su, Qiong Wu, Hongbo Liu, Yan Zhang
    Nucleic acids research 2016:44(D1)
    1 Citations (Google Scholar as of 2016-01-27)

    Abstract: Super-enhancers are large clusters of transcriptional enhancers regarded as having essential roles in driving the expression of genes that control cell identity during development and tumorigenesis. The construction of a genome-wide super-enhancer database is urgently needed to better understand super-enhancer-directed gene expression regulation for a given biology process. Here, we present a specifically designed web-accessible database, Super-Enhancer Archive (SEA, http://sea.edbc.org). SEA focuses on integrating super-enhancers in multiple species and annotating their potential roles in the regulation of cell identity gene expression. The current release of SEA incorporates 83 996 super-enhancers computationally or experimentally identified in 134 cell types/tissues/diseases, including human (75 439, three of which were experimentally identified), mouse (5879, five of which were experimentally identified), Drosophila melanogaster (1774) and Caenorhabditis elegans (904). To facilitate data extraction, SEA supports multiple search options, including species, genome location, gene name, cell type/tissue and super-enhancer name. The response provides detailed (epi)genetic information, incorporating cell type specificity, nearby genes, transcriptional factor binding sites, CRISPR/Cas9 target sites, evolutionary conservation, SNPs, H3K27ac, DNA methylation, gene expression and TF ChIP-seq data. Moreover, analytical tools and a genome browser were developed for users to explore super-enhancers and their roles in defining cell identity and disease processes in depth. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

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Rate of accessibility:
HTTP status codeDate requested
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200 OK2018-01-12
200 OK2018-01-09
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200 OK2018-01-02
200 OK2017-12-29
200 OK2017-12-26
200 OK2017-12-22
200 OK2017-12-19
200 OK2017-12-15
200 OK2017-12-12
200 OK2017-12-08
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200 OK2017-12-01
200 OK2017-11-28
200 OK2017-11-24
200 OK2017-11-21
200 OK2017-11-17
200 OK2017-11-14
200 OK2017-11-10
200 OK2017-11-07
200 OK2017-11-03
200 OK2017-10-31
200 OK2017-10-27
200 OK2017-10-24
200 OK2017-10-20
200 OK2017-10-17
200 OK2017-10-13
200 OK2017-10-10
200 OK2017-10-06
200 OK2017-10-03
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-1 Failed2017-09-15
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200 OK2017-08-15
-1 Failed2017-08-11
200 OK2017-08-08
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200 OK2017-07-04
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200 OK2017-05-09
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200 OK2017-02-21
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200 OK2017-02-14
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200 OK2017-02-07
200 OK2017-02-03
200 OK2017-01-31
200 OK2017-01-27
200 OK2017-01-24
200 OK2017-01-20
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200 OK2017-01-03
200 OK2016-12-30
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200 OK2016-11-15
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200 OK2016-11-08
200 OK2016-11-04
200 OK2016-11-01
200 OK2016-10-28
200 OK2016-10-25
200 OK2016-10-21
200 OK2016-10-18
200 OK2016-10-14
200 OK2016-10-11
502 Failed2016-10-07
200 OK2016-10-04
200 OK2016-09-30
200 OK2016-09-27
200 OK2016-09-23
200 OK2016-09-20
200 OK2016-09-16
200 OK2016-09-13
200 OK2016-09-09
200 OK2016-09-06
200 OK2016-09-02
200 OK2016-08-30
200 OK2016-08-26
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200 OK2016-08-19
200 OK2016-08-16
200 OK2016-08-12
200 OK2016-08-09
200 OK2016-08-05
200 OK2016-08-02
200 OK2016-07-29
200 OK2016-07-26
200 OK2016-07-22
200 OK2016-07-19
200 OK2016-07-15
200 OK2016-07-12
200 OK2016-07-08
200 OK2016-07-05
200 OK2016-07-01
200 OK2016-06-28
200 OK2016-06-24
200 OK2016-06-21
200 OK2016-06-17
200 OK2016-06-14
200 OK2016-06-10
200 OK2016-06-07
200 OK2016-06-03
200 OK2016-05-31
200 OK2016-05-27
200 OK2016-05-24
200 OK2016-05-20
200 OK2016-05-17
200 OK2016-05-13
200 OK2016-05-10
200 OK2016-05-06
200 OK2016-05-03
200 OK2016-04-29
200 OK2016-04-26
200 OK2016-04-22
200 OK2016-04-19
200 OK2016-04-15
200 OK2016-04-12
200 OK2016-04-08
200 OK2016-04-05
200 OK2016-04-01
200 OK2016-03-29
200 OK2016-03-28
200 OK2016-03-25
200 OK2016-03-23
200 OK2016-03-21
200 OK2016-03-18
200 OK2016-03-16
200 OK2016-03-14
200 OK2016-03-11
200 OK2016-03-09
200 OK2016-03-07
200 OK2016-03-04
200 OK2016-03-02
200 OK2016-02-29
200 OK2016-02-26
200 OK2016-02-24
200 OK2016-02-22
200 OK2016-02-19
200 OK2016-02-17
200 OK2016-02-15
200 OK2016-02-14
200 OK2016-02-12
200 OK2016-02-10
200 OK2016-02-08
200 OK2016-02-07
200 OK2016-02-05
200 OK2016-02-03
200 OK2016-02-01
200 OK2016-01-31
200 OK2016-01-29
200 OK2016-01-27
200 OK2016-01-25
200 OK2016-01-24
200 OK2016-01-22
200 OK2016-01-20
200 OK2016-01-18
200 OK2016-01-17
200 OK2016-01-15
200 OK2016-01-13
200 OK2016-01-11
200 OK2016-01-10
200 OK2016-01-08
200 OK2016-01-06

Tags

DNA Expression Modification
Caenorhabditis elegans Drosophila melanogaster Homo sapiens Mus musculus
gene expression super-enhancer

Record metadata

  • Created on: 2016-01-06
  • Curated by:
    • Lin Xia [2016-03-29]
    • Lin Liu [2016-02-08]
    • Lin Liu [2016-01-27]
    • Lin Liu [2016-01-06]
Stats