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Database Commons - FARE-CAFE

FARE-CAFE

Citations: 1

z-index 0.21

Short name FARE-CAFE
Full name Database of Functional and Regulatory Elements of Cancer-Associated Fusion Events
Description FARE-CAFE is a database of functional and regulatory elements of cancer-associated fusion events. It is a database with the combination of the cancer related chromosomal translation events, fusion genes, domains, domain-domain interactions (DDI), protein-protein interactions (PPI), transcription factors(TF) and miRNAs collectively with the consequent experimental information.
URL http://ppi.bioinfo.asia.edu.tw/FARE-CAFE/
Year founded 2015
Last update & version 2015-09-16    v1.0
Availability Free to all users
University/Institution hosted Asia University
Address Department of Bioinformatics and Medical Engineering, Asia University, Taichung 41354, Taiwan
City Taichung
Province/State
Country/Region Taiwan
Contact name Ka-LoK Ng
Contact email ppiddi@gmail.com
Data type(s)
Major organism(s)
Keyword(s)
  • cancer
  • domain-domain interactions (DDI)
  • fusion gene
  • miRNA
  • protein-protein interaction (PPI)
  • transcription factor
Publication(s)
  • FARE-CAFE: a database of functional and regulatory elements of cancer-associated fusion events. [PMID: 26384373]

    Praveen Kumar Korla, Jack Cheng, Chien-Hung Huang, Jeffrey J P Tsai, Yu-Hsuan Liu, Nilubon Kurubanjerdjit, Wen-Tsong Hsieh, Huey-Yi Chen, Ka-Lok Ng
    Database : the journal of biological databases and curation 2015:2015
    1 Citations (Google Scholar as of 2016-09-23)

    Abstract: Chromosomal translocation (CT) is of enormous clinical interest because this disorder is associated with various major solid tumors and leukemia. A tumor-specific fusion gene event may occur when a translocation joins two separate genes. Currently, various CT databases provide information about fusion genes and their genomic elements. However, no database of the roles of fusion genes, in terms of essential functional and regulatory elements in oncogenesis, is available. FARE-CAFE is a unique combination of CTs, fusion proteins, protein domains, domain-domain interactions, protein-protein interactions, transcription factors and microRNAs, with subsequent experimental information, which cannot be found in any other CT database. Genomic DNA information including, for example, manually collected exact locations of the first and second break points, sequences and karyotypes of fusion genes are included. FARE-CAFE will substantially facilitate the cancer biologist's mission of elucidating the pathogenesis of various types of cancer. This database will ultimately help to develop 'novel' therapeutic approaches. Database URL: http://ppi.bioinfo.asia.edu.tw/FARE-CAFE. © The Author(s) 2015. Published by Oxford University Press.

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Tags

Disease DNA Interaction and Network Protein
Homo sapiens
cancer domain-domain interactions (DDI) fusion gene miRNA protein-protein interaction (PPI) transcription factor

Record metadata

  • Created on: 2016-01-15
  • Curated by:
    • Lina Ma [2016-09-23]
    • Lina Ma [2016-04-08]
    • Jian Sang [2016-04-03]
    • Lina Ma [2016-03-30]
    • Mengwei Li [2016-01-15]
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