Database Commons a catalog of biological databases

Database Commons - OCDB

OCDB

Citations: 1

z-index 0.14

Short name OCDB
Full name Obsessive-Compulsive Disorder Database
Description OCDB is the first overall database collecting genes, miRNAs and drugs for Obsessive-Compulsive Disorder.
URL http://alpha.dmi.unict.it/ocdb/
Year founded 2015
Last update & version 2015-07-29    
Availability Free to all users
University/Institution hosted University of Catania
Address Viale A. Doria 6, Catania, Italy
City Catania
Province/State
Country/Region Italy
Contact name Rosalba Giugno
Contact email giugno@dmi.unict.it
Data type(s)
Major organism(s)
Keyword(s)
  • obsessive-compulsive disorder
Publication(s)
  • OCDB: a database collecting genes, miRNAs and drugs for obsessive-compulsive disorder. [PMID: 26228432]

    Anna P Privitera, Rosario Distefano, Hugo A Wefer, Alfredo Ferro, Alfredo Pulvirenti, Rosalba Giugno
    Database : the journal of biological databases and curation 2015:2015
    1 Citations (Google Scholar as of 2016-03-28)

    Abstract: Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by intrusive and unwilling thoughts (obsessions) giving rise to anxiety. The patients feel obliged to perform a behavior (compulsions) induced by the obsessions. The World Health Organization ranks OCD as one of the 10 most disabling medical conditions. In the class of Anxiety Disorders, OCD is a pathology that shows an hereditary component. Consequently, an online resource collecting and integrating scientific discoveries and genetic evidence about OCD would be helpful to improve the current knowledge on this disorder. We have developed a manually curated database, OCD Database (OCDB), collecting the relations between candidate genes in OCD, microRNAs (miRNAs) involved in the pathophysiology of OCD and drugs used in its treatments. We have screened articles from PubMed and MEDLINE. For each gene, the bibliographic references with a brief description of the gene and the experimental conditions are shown. The database also lists the polymorphisms within genes and its chromosomal regions. OCDB data is enriched with both validated and predicted miRNA-target and drug-target information. The transcription factors regulations, which are also included, are taken from David and TransmiR. Moreover, a scoring function ranks the relevance of data in the OCDB context. The database is also integrated with the main online resources (PubMed, Entrez-gene, HGNC, dbSNP, DrugBank, miRBase, PubChem, Kegg, Disease-ontology and ChEBI). The web interface has been developed using phpMyAdmin and Bootstrap software. This allows (i) to browse data by category and (ii) to navigate in the database by searching genes, miRNAs, drugs, SNPs, regions, drug targets and articles. The data can be exported in textual format as well as the whole database in.sql or tabular format. OCDB is an essential resource to support genome-wide analysis, genetic and pharmacological studies. It also facilitates the evaluation of genetic data in OCD and the detection of alternative treatments. © The Author(s) 2015. Published by Oxford University Press.

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Tags

Disease DNA Drug and Chemical Compound RNA
Homo sapiens
obsessive-compulsive disorder

Record metadata

  • Created on: 2016-01-15
  • Curated by:
    • Lin Liu [2016-03-28]
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