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Database Commons - OnTheFly

OnTheFly

Citations: 9

z-index 0.58

Short name OnTheFly
Full name TF and TFBS On The Fly
Description A database of Drosophila melanogaster transcription factors and their binding sites
URL https://bhapp.c2b2.columbia.edu/OnTheFly/index.php
Year founded 2013
Last update & version 2015-5    v1.0
Availability Free to all users
University/Institution hosted Columbia University
Address 1130 St. Nicholas Avenue, New York, NY 10032, USA
City New York
Province/State NY
Country/Region United States
Contact name Richard S. Mann
Contact email ss4179@columbia.edu
Data type(s)
Major organism(s)
Keyword(s)
  • transcription factor binding site
Publication(s)
  • OnTheFly: a database of Drosophila melanogaster transcription factors and their binding sites. [PMID: 24271386]

    Shula Shazman, Hunjoong Lee, Yakov Socol, Richard S Mann, Barry Honig
    Nucleic acids research 2014:42(Database issue)
    9 Citations (Google Scholar as of 2016-06-09)

    Abstract: We present OnTheFly (http://bhapp.c2b2.columbia.edu/OnTheFly/index.php), a database comprising a systematic collection of transcription factors (TFs) of Drosophila melanogaster and their DNA-binding sites. TFs predicted in the Drosophila melanogaster genome are annotated and classified and their structures, obtained via experiment or homology models, are provided. All known preferred TF DNA-binding sites obtained from the B1H, DNase I and SELEX methodologies are presented. DNA shape parameters predicted for these sites are obtained from a high throughput server or from crystal structures of protein-DNA complexes where available. An important feature of the database is that all DNA-binding domains and their binding sites are fully annotated in a eukaryote using structural criteria and evolutionary homology. OnTheFly thus provides a comprehensive view of TFs and their binding sites that will be a valuable resource for deciphering non-coding regulatory DNA.

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Tags

DNA Protein
Drosophila melanogaster
transcription factor binding site

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Lina Ma [2016-09-26]
    • Lin Liu [2016-03-28]
    • Zhang Zhang [2016-01-04]
    • Li Yang [2015-11-24]
    • Li Yang [2015-06-26]
Stats