Database Commons a catalog of biological databases

Database Commons - BloodChIP

BloodChIP

Citations: 11

z-index 0.80

Short name BloodChIP
Full name
Description BloodChIP is a database of comparative genome-wide transcription factor binding profiles in human blood cells.
URL http://www.med.unsw.edu.au/CRCWeb.nsf/page/BloodChIP
Year founded 2013
Last update & version 9/20/2013    v1.0
Availability Free to all users
University/Institution hosted University of New South Wales
Address Sydney, NSW 2052, Australia
City Sydney
Province/State NSW
Country/Region Australia
Contact name John E. Pimanda
Contact email jpimanda@unsw.edu.au
Data type(s)
Major organism(s)
Keyword(s)
  • blood
Publication(s)
  • BloodChIP: a database of comparative genome-wide transcription factor binding profiles in human blood cells. [PMID: 24185696]

    Diego Chacon, Dominik Beck, Dilmi Perera, Jason W H Wong, John E Pimanda
    Nucleic acids research 2014:42(Database issue)
    11 Citations (Google Scholar as of 2016-06-09)

    Abstract: The BloodChIP database (http://www.med.unsw.edu.au/CRCWeb.nsf/page/BloodChIP) supports exploration and visualization of combinatorial transcription factor (TF) binding at a particular locus in human CD34-positive and other normal and leukaemic cells or retrieval of target gene sets for user-defined combinations of TFs across one or more cell types. Increasing numbers of genome-wide TF binding profiles are being added to public repositories, and this trend is likely to continue. For the power of these data sets to be fully harnessed by experimental scientists, there is a need for these data to be placed in context and easily accessible for downstream applications. To this end, we have built a user-friendly database that has at its core the genome-wide binding profiles of seven key haematopoietic TFs in human stem/progenitor cells. These binding profiles are compared with binding profiles in normal differentiated and leukaemic cells. We have integrated these TF binding profiles with chromatin marks and expression data in normal and leukaemic cell fractions. All queries can be exported into external sites to construct TF-gene and protein-protein networks and to evaluate the association of genes with cellular processes and tissue expression.

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Tags

DNA Interaction and Network Protein
Homo sapiens
blood

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Mengwei Li [2016-03-31]
    • Mengwei Li [2016-03-29]
    • Zhang Zhang [2016-01-04]
    • Mengwei Li [2015-06-26]
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