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Database Commons - HLA-ADR

HLA-ADR

Citations: 2

z-index 1.00

Short name HLA-ADR
Full name Human leukocyte antigens Adverse Drug Reaction Database
Description HLA-ADR is part of the Allele Frequencies Net Database (AFND). The main aim of this module is to provide users with an open database listing known adverse drug reactions with HLA alleles.
URL http://www.allelefrequencies.net/hla-adr/
Year founded 2016
Last update & version 2016-05-17    
Availability Free to all users
University/Institution hosted Institute of Integrative Biology
Address L7 8XP
City Liverpool
Province/State
Country/Region United Kingdom
Contact name Andrew R. Jones
Contact email andrew.jones@liverpool.ac.uk
Data type(s)
Major organism(s)
Keyword(s)
  • adverse drug reaction
  • HLA allele
  • human leukocyte antigen
Publication(s)
  • A web resource for mining HLA associations with adverse drug reactions: HLA-ADR. [PMID: 27189608]

    Gurpreet S Ghattaoraya, Yenal Dundar, Faviel F González-Galarza, Maria Helena Thomaz Maia, Eduardo José Melo Santos, Andréa Luciana Soares da Silva, Antony McCabe, Derek Middleton, Ana Alfirevic, Rumona Dickson, Andrew R Jones
    Database : the journal of biological databases and curation 2016:2016
    2 Citations (Google Scholar as of 2017-02-28)

    Abstract: Human leukocyte antigens (HLA) are an important family of genes involved in the immune system. Their primary function is to allow the host immune system to be able to distinguish between self and non-self peptides-e.g. derived from invading pathogens. However, these genes have also been implicated in immune-mediated adverse drug reactions (ADRs), presenting a problem to patients, clinicians and pharmaceutical companies. We have previously developed the Allele Frequency Net Database (AFND) that captures the allelic and haplotype frequencies for these HLA genes across many healthy populations from around the world. Here, we report the development and release of the HLA-ADR database that captures data from publications where HLA alleles and haplotypes have been associated with ADRs (e.g. Stevens-Johnson Syndrome/toxic epidermal necrolysis and drug-induced liver injury). HLA-ADR was created by using data obtained through systematic review of the literature and semi-automated literature mining. The database also draws on data already present in AFND allowing users to compare and analyze allele frequencies in both ADR patients and healthy populations. The HLA-ADR database provides clinicians and researchers with a centralized resource from which to investigate immune-mediated ADRs.Database URL: http://www.allelefrequencies.net/hla-adr/. © The Author(s) 2016. Published by Oxford University Press.

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Accessibility

Rate of accessibility:
HTTP status codeDate requested
200 OK2018-11-16
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200 OK2018-10-19
200 OK2018-10-16
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200 OK2018-10-09
200 OK2018-10-05
200 OK2018-10-02
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200 OK2018-04-24
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200 OK2018-04-03
200 OK2018-02-27
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200 OK2018-02-20
200 OK2018-02-16
200 OK2018-02-13
200 OK2018-02-09
200 OK2018-02-06
200 OK2018-02-02
200 OK2018-01-30
200 OK2018-01-26
200 OK2018-01-23
200 OK2018-01-19
200 OK2018-01-16
200 OK2018-01-12
200 OK2018-01-09
200 OK2018-01-05
200 OK2018-01-02
200 OK2017-12-29
200 OK2017-12-26
200 OK2017-12-22
200 OK2017-12-19
200 OK2017-12-15
200 OK2017-12-12
200 OK2017-12-08
200 OK2017-12-05
200 OK2017-12-01
200 OK2017-11-28
200 OK2017-11-24
200 OK2017-11-21
200 OK2017-11-17
200 OK2017-11-14
200 OK2017-11-10
200 OK2017-11-07
200 OK2017-11-03
200 OK2017-10-31
200 OK2017-10-27
200 OK2017-10-24
200 OK2017-10-20
200 OK2017-10-17
200 OK2017-10-13
200 OK2017-10-10
200 OK2017-10-06
200 OK2017-10-03
200 OK2017-09-29
200 OK2017-09-26
200 OK2017-09-22
200 OK2017-09-19
200 OK2017-09-15
200 OK2017-09-12
200 OK2017-09-08
200 OK2017-09-05
200 OK2017-09-01
200 OK2017-08-29
200 OK2017-08-25
200 OK2017-08-22
200 OK2017-08-18
200 OK2017-08-15
200 OK2017-08-11
200 OK2017-08-08
200 OK2017-08-04
200 OK2017-08-01
200 OK2017-07-28
200 OK2017-07-25
200 OK2017-07-21
200 OK2017-07-18
200 OK2017-07-14
200 OK2017-07-04
200 OK2017-06-30
200 OK2017-06-27
200 OK2017-06-23
200 OK2017-06-20
200 OK2017-06-16
200 OK2017-06-13
200 OK2017-06-09
200 OK2017-06-06
200 OK2017-06-02
200 OK2017-05-30
200 OK2017-05-26
200 OK2017-05-23
200 OK2017-05-19
200 OK2017-05-16
200 OK2017-05-12
200 OK2017-05-09
200 OK2017-05-05
200 OK2017-05-02
200 OK2017-04-28
200 OK2017-04-25
200 OK2017-04-21
200 OK2017-04-18
200 OK2017-04-14
200 OK2017-04-11
200 OK2017-04-07
200 OK2017-04-04
200 OK2017-03-31
200 OK2017-03-28
200 OK2017-03-24
200 OK2017-03-21
200 OK2017-03-17
200 OK2017-03-14
200 OK2017-03-10
200 OK2017-03-07
200 OK2017-03-03
200 OK2017-02-28

Tags

Drug and Chemical Compound
Homo sapiens
adverse drug reaction HLA allele human leukocyte antigen

Record metadata

  • Created on: 2017-02-28
  • Curated by:
    • Lina Ma [2017-06-05]
    • Shixiang Sun [2017-02-28]
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