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Database Commons - SwissSidechain

SwissSidechain

Citations: 16

z-index 2.53

Short name SwissSidechain
Full name A Molecular and Structural Database of Non-natural Sidechains
Description SwissSidechain is a structural and molecular mechanics database of hundreds of non-natural amino-acid sidechains that can be used to study in silico their insertion into natural peptides or proteins
URL http://www.swisssidechain.ch/
Year founded 2012
Last update & version 2012-01-11    v1.0
Availability Free to all users
University/Institution hosted Swiss Institute of Bioinformatics
Address Genopode 1015 Lausanne
City Lausanne
Province/State
Country/Region Switzerland
Contact name Vincent Zoete
Contact email vincent.zoete@unil.ch
Data type(s)
Major organism(s)
Keyword(s)
  • 2D structure
  • biochemistry
  • medicinal chemistry
  • molecular modeling
  • protein engineering
Publication(s)
  • SwissSidechain: a molecular and structural database of non-natural sidechains. [PMID: 23104376]

    David Gfeller, Olivier Michielin, Vincent Zoete
    Nucleic acids research 2013:41(Database issue)
    16 Citations (Google Scholar as of 2016-01-14)

    Abstract: Amino acids form the building blocks of all proteins. Naturally occurring amino acids are restricted to a few tens of sidechains, even when considering post-translational modifications and rare amino acids such as selenocysteine and pyrrolysine. However, the potential chemical diversity of amino acid sidechains is nearly infinite. Exploiting this diversity by using non-natural sidechains to expand the building blocks of proteins and peptides has recently found widespread applications in biochemistry, protein engineering and drug design. Despite these applications, there is currently no unified online bioinformatics resource for non-natural sidechains. With the SwissSidechain database (http://www.swisssidechain.ch), we offer a central and curated platform about non-natural sidechains for researchers in biochemistry, medicinal chemistry, protein engineering and molecular modeling. SwissSidechain provides biophysical, structural and molecular data for hundreds of commercially available non-natural amino acid sidechains, both in l- and d-configurations. The database can be easily browsed by sidechain names, families or physico-chemical properties. We also provide plugins to seamlessly insert non-natural sidechains into peptides and proteins using molecular visualization software, as well as topologies and parameters compatible with molecular mechanics software.

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200 OK2016-01-29
200 OK2016-01-27
200 OK2016-01-25
200 OK2016-01-24
200 OK2016-01-22
200 OK2016-01-20
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200 OK2016-01-17
200 OK2016-01-15
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200 OK2016-01-11
200 OK2016-01-10
200 OK2016-01-08
200 OK2016-01-06
200 OK2016-01-04

Tags

DNA Metabolic and Signaling Pathway Protein
2D structure biochemistry medicinal chemistry molecular modeling protein engineering

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Lin Xia [2016-03-28]
    • Mengwei Li [2016-02-21]
    • Lin Xia [2015-06-26]
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