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Database Commons - ESTHER

ESTHER

Citations: 47

z-index 3.10

Short name ESTHER
Full name The database of ESTerases and alpha/beta-Hydrolase Enzymes and Relatives
Description The ESTHER database is dedicated to the analysis of proteins or protein domains belonging to the superfamily of alpha/beta-hydrolases, exemplified by the cholinesterases
URL http://bioweb.ensam.inra.fr/esther
Year founded 2012
Last update & version 2015-5-13    v1.0
Availability Free to all users
University/Institution hosted Dynamique Musculaire et Métabolisme
Address Dynamique Musculaire et Métabolisme, INRA-UM1, Place Viala, 34060 Montpellier, France
City Montpellier
Province/State
Country/Region France
Contact name Arnaud Chatonnet
Contact email chatonne@supagro.inra.fr
Data type(s)
Major organism(s)
Keyword(s)
  • alpha/beta-hydrolases
  • cholinesterases
Publication(s)
  • ESTHER, the database of the α/β-hydrolase fold superfamily of proteins: tools to explore diversity of functions. [PMID: 23193256]

    Nicolas Lenfant, Thierry Hotelier, Eric Velluet, Yves Bourne, Pascale Marchot, Arnaud Chatonnet
    Nucleic acids research 2013:41(Database issue)
    47 Citations (Google Scholar as of 2016-01-18)

    Abstract: The ESTHER database, which is freely available via a web server (http://bioweb.ensam.inra.fr/esther) and is widely used, is dedicated to proteins with an α/β-hydrolase fold, and it currently contains >30 000 manually curated proteins. Herein, we report those substantial changes towards improvement that we have made to improve ESTHER during the past 8 years since our 2004 update. In particular, we generated 87 new families and increased the coverage of the UniProt Knowledgebase (UniProtKB). We also renewed the ESTHER website and added new visualization tools, such as the Overall Table and the Family Tree. We also address two topics of particular interest to the ESTHER users. First, we explain how the different enzyme classifications (bacterial lipases, peptidases, carboxylesterases) used by different communities of users are combined in ESTHER. Second, we discuss how variations of core architecture or in predicted active site residues result in a more precise clustering of families, and whether this strategy provides trustable hints to identify enzyme-like proteins with no catalytic activity.

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Tags

Protein
alpha/beta-hydrolases cholinesterases

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Jian Sang [2016-04-05]
    • Zhang Zhang [2016-01-18]
    • Jian Sang [2015-12-11]
    • Jian Sang [2015-06-28]
    • Jian Sang [2015-06-27]
Stats