Database Commons a catalog of biological databases

Database Commons - HBVdb

HBVdb

Citations: 16

z-index 1.63

Short name HBVdb
Full name Hepatitis B Virus database
Description HBVdb allows the researchers to investigate the genetic variability of Hepatitis B Virus (HBV) and viral resistance to treatment.
URL https://hbvdb.ibcp.fr/
Year founded 1998
Last update & version 2016-04-10    v31.0
Availability Free to all users
University/Institution hosted Université Claude Bernard Lyon 1
Address Unité Bases Moléculaires et Structurales des Systèmes Infectieux, Lyon, France
City Lyon
Province/State
Country/Region France
Contact name Christophe Combet
Contact email christophe.combet@ibcp.fr
Data type(s)
Major organism(s)
Keyword(s)
  • drug resistance profile
  • interaction of genotype and phenotype
  • sequence annotation
Publication(s)
  • HBVdb: a knowledge database for Hepatitis B Virus. [PMID: 23125365]

    Juliette Hayer, Fanny Jadeau, Gilbert Deléage, Alan Kay, Fabien Zoulim, Christophe Combet
    Nucleic acids research 2013:41(Database issue)
    16 Citations (Google Scholar as of 2016-01-23)

    Abstract: We have developed a specialized database, HBVdb (http://hbvdb.ibcp.fr), allowing the researchers to investigate the genetic variability of Hepatitis B Virus (HBV) and viral resistance to treatment. HBV is a major health problem worldwide with more than 350 million individuals being chronically infected. HBV is an enveloped DNA virus that replicates by reverse transcription of an RNA intermediate. HBV genome is optimized, being circular and encoding four overlapping reading frames. Indeed, each nucleotide of the genome takes part in the coding of at least one protein. However, HBV shows some genome variability leading to at least eight different genotypes and recombinant forms. The main drugs used to treat infected patients are nucleos(t)ides analogs (reverse transcriptase inhibitors). Unfortunately, HBV mutants resistant to these drugs may be selected and be responsible for treatment failure. HBVdb contains a collection of computer-annotated sequences based on manually annotated reference genomes. The database can be accessed through a web interface that allows static and dynamic queries and offers integrated generic sequence analysis tools and specialized analysis tools (e.g. annotation, genotyping, drug resistance profiling).

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Accessibility

Rate of accessibility:
HTTP status codeDate requested
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200 OK2018-08-14
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200 OK2018-08-07
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200 OK2018-07-27
200 OK2018-07-24
200 OK2018-07-20
200 OK2018-07-17
200 OK2018-07-13
200 OK2018-07-10
200 OK2018-07-06
200 OK2018-07-03
200 OK2018-06-29
200 OK2018-06-26
200 OK2018-06-22
200 OK2018-06-19
200 OK2018-06-15
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200 OK2018-05-01
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200 OK2018-04-24
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200 OK2018-04-17
200 OK2018-04-13
200 OK2018-04-10
200 OK2018-04-06
200 OK2018-04-03
200 OK2018-02-27
200 OK2018-02-23
200 OK2018-02-20
200 OK2018-02-16
200 OK2018-02-13
200 OK2018-02-09
200 OK2018-02-06
200 OK2018-02-02
200 OK2018-01-30
200 OK2018-01-26
200 OK2018-01-23
200 OK2018-01-19
200 OK2018-01-16
200 OK2018-01-12
200 OK2018-01-09
200 OK2018-01-05
200 OK2018-01-02
200 OK2017-12-29
200 OK2017-12-26
200 OK2017-12-22
200 OK2017-12-19
200 OK2017-12-15
200 OK2017-12-12
200 OK2017-12-08
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200 OK2017-12-01
200 OK2017-11-28
200 OK2017-11-24
200 OK2017-11-21
200 OK2017-11-17
200 OK2017-11-14
200 OK2017-11-10
-1 Failed2017-11-07
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-1 Failed2016-07-19
-1 Failed2016-07-15
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-1 Failed2016-07-08
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-1 Failed2016-06-28
-1 Failed2016-06-24
-1 Failed2016-06-21
-1 Failed2016-06-17
-1 Failed2016-06-14
-1 Failed2016-06-10
-1 Failed2016-06-07
-1 Failed2016-06-03
-1 Failed2016-05-31
-1 Failed2016-05-27
200 OK2016-05-24
200 OK2016-05-20
200 OK2016-05-17
200 OK2016-05-13
200 OK2016-05-10
200 OK2016-05-06
200 OK2016-05-03
200 OK2016-04-29
200 OK2016-04-26
200 OK2016-04-22
-1 Failed2016-04-19
200 OK2016-04-15
200 OK2016-04-12
200 OK2016-04-08
200 OK2016-04-05
200 OK2016-04-01
200 OK2016-03-29
200 OK2016-03-28
200 OK2016-03-25
200 OK2016-03-23
200 OK2016-03-21
200 OK2016-03-18
200 OK2016-03-16
200 OK2016-03-14
200 OK2016-03-11
200 OK2016-03-09
200 OK2016-03-07
200 OK2016-03-04
200 OK2016-03-02
200 OK2016-02-29
200 OK2016-02-26
200 OK2016-02-24
200 OK2016-02-22
200 OK2016-02-19
200 OK2016-02-17
200 OK2016-02-15
200 OK2016-02-14
200 OK2016-02-12
200 OK2016-02-10
200 OK2016-02-08
200 OK2016-02-07
200 OK2016-02-05
200 OK2016-02-03
200 OK2016-02-01
200 OK2016-01-31
200 OK2016-01-29
200 OK2016-01-27
200 OK2016-01-25
200 OK2016-01-24
200 OK2016-01-22
200 OK2016-01-20
200 OK2016-01-18
200 OK2016-01-17
200 OK2016-01-15
200 OK2016-01-13
200 OK2016-01-11
200 OK2016-01-10
200 OK2016-01-08
200 OK2016-01-06
200 OK2016-01-04

Tags

DNA
Homo sapiens
drug resistance profile interaction of genotype and phenotype sequence annotation

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Chunlei Yu [2016-04-17]
    • Chunlei Yu [2016-03-31]
    • Mengwei Li [2016-02-19]
    • Chunlei Yu [2015-11-19]
    • Chunlei Yu [2015-06-30]
    • Chunlei Yu [2015-06-26]
Stats