- IUPHAR-DB: updated database content and new features. [PMID: 23087376]
Joanna L Sharman, Helen E Benson, Adam J Pawson, Veny Lukito, Chidochangu P Mpamhanga, Vincent Bombail, Anthony P Davenport, John A Peters, Michael Spedding, Anthony J Harmar, null null
Nucleic acids research 2013:41(Database issue)
58 Citations (Google Scholar as of 2016-03-01)
Abstract: The International Union of Basic and Clinical Pharmacology (IUPHAR) database, IUPHAR-DB (http://www.iuphar-db.org) is an open access, online database providing detailed, expert-driven annotation of the primary literature on human and rodent receptors and other drug targets, together with the substances that act on them. The present release includes information on the products of 646 genes from four major protein classes (G protein-coupled receptors, nuclear hormone receptors, voltage- and ligand-gated ion channels) and ?3180 bioactive molecules (endogenous ligands, licensed drugs and key pharmacological tools) that interact with them. We have described previously the classification and curation of data for small molecule ligands in the database; in this update we have annotated 366 endogenous peptide ligands with their amino acid sequences, post-translational modifications, links to precursor genes, species differences and relationships with other molecules in the database (e.g. those derived from the same precursor). We have also matched targets with their endogenous ligands (peptides and small molecules), with particular attention paid to identifying bioactive peptide ligands generated by post-translational modification of precursor proteins. Other improvements to the database include enhanced information on the clinical relevance of targets and ligands in the database, more extensive links to other databases and a pilot project for the curation of enzymes as drug targets.
- IUPHAR-DB: new receptors and tools for easy searching and visualization of pharmacological data. [PMID: 21087994]
Joanna L Sharman, Chidochangu P Mpamhanga, Michael Spedding, Pierre Germain, Bart Staels, Catherine Dacquet, Vincent Laudet, Anthony J Harmar, null null
Nucleic acids research 2011:39(Database issue)
86 Citations (Google Scholar as of 2016-03-01)
Abstract: The IUPHAR database is an established online reference resource for several important classes of human drug targets and related proteins. As well as providing recommended nomenclature, the database integrates information on the chemical, genetic, functional and pathophysiological properties of receptors and ion channels, curated and peer-reviewed from the biomedical literature by a network of experts. The database now includes information on 616 gene products from four superfamilies in human and rodent model organisms: G protein-coupled receptors, voltage- and ligand-gated ion channels and, in a recent update, 49 nuclear hormone receptors (NHRs). New data types for NHRs include details on co-regulators, DNA binding motifs, target genes and 3D structures. Other recent developments include curation of the chemical structures of approximately 2000 ligand molecules, providing electronic descriptors, identifiers, link-outs and calculated molecular properties, all available via enhanced ligand pages. The interface now provides intelligent tools for the visualization and exploration of ligand structure-activity relationships and the structural diversity of compounds active at each target. The database is freely available at http://www.iuphar-db.org.