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Database Commons - G4LDB

G4LDB

Citations: 24

z-index 3.02

Short name G4LDB
Full name G-quadruplex ligands database
Description G4LDB provides a unique collection of reported G-quadruplex ligands to streamline ligand/drug discovery targeting G-quadruplexes.
URL http://www.g4ldb.org/ci2/index.php
Year founded 2012
Last update & version NA    v1.0
Availability Free to all users
University/Institution hosted Institute of Chemistry, Chinese Academy of Sciences
Address Beijing National Laboratory for Molecular Sciences (BNLMS),Center for Molecular Sciences,State Key Laboratory for Structural Chemistry of Unstable and Stable Species,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,PR China
City Beijing
Province/State
Country/Region China
Contact name Ya-Lin Tang
Contact email tangyl@iccas.ac.cn
Data type(s)
Major organism(s)
Keyword(s)
  • g-quadruplexes
  • ligands
Publication(s)
  • G4LDB: a database for discovering and studying G-quadruplex ligands. [PMID: 23161677]

    Qian Li, Jun-Feng Xiang, Qian-Fan Yang, Hong-Xia Sun, Ai-Jiao Guan, Ya-Lin Tang
    Nucleic acids research 2013:41(Database issue)
    24 Citations (Google Scholar as of 2016-03-02)

    Abstract: The G-quadruplex ligands database (G4LDB, http://www.g4ldb.org) provides a unique collection of reported G-quadruplex ligands to streamline ligand/drug discovery targeting G-quadruplexes. G-quadruplexes are guanine-rich nucleic acid sequences in human telomeres and gene promoter regions. There is a growing recognition for their profound roles in a wide spectrum of diseases, such as cancer, diabetes and cardiovascular disease. Ligands that affect the structure and activity of G-quadruplexes can shed light on the search for G-quadruplex-targeting drugs. Therefore, we built the G4LDB to (i) compile a data set covering various physical properties and 3D structure of G-quadruplex ligands; (ii) provide Web-based tools for G-quadruplex ligand design; and (iii) to facilitate the discovery of novel therapeutic and diagnostic agents targeting G-quadruplexes. G4LDB currently contains >800?G-quadruplex ligands with ?4000 activity records, which, to our knowledge, is the most extensive collection of its kind. It offers a user friendly interface that can meet a variety of data inquiries from researchers. For example, ligands can be searched for by name, molecular properties, structures, ligand activities and so on. Building on the reported data, the database also provides an online ligand design module that can predict ligand binding affinity in real time.

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Accessibility

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200 OK2018-01-23
200 OK2018-01-19
200 OK2018-01-16
200 OK2018-01-12
200 OK2018-01-09
200 OK2018-01-05
200 OK2018-01-02
200 OK2017-12-29
200 OK2017-12-26
200 OK2017-12-22
200 OK2017-12-19
200 OK2017-12-15
200 OK2017-12-12
200 OK2017-12-08
200 OK2017-12-05
200 OK2017-12-01
200 OK2017-11-28
200 OK2017-11-24
200 OK2017-11-21
200 OK2017-11-17
200 OK2017-11-14
200 OK2017-11-10
200 OK2017-11-07
200 OK2017-11-03
200 OK2017-10-31
200 OK2017-10-27
200 OK2017-10-24
200 OK2017-10-20
200 OK2017-10-17
200 OK2017-10-13
200 OK2017-10-10
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200 OK2017-09-19
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200 OK2017-03-14
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200 OK2017-03-07
200 OK2017-03-03
200 OK2017-02-28
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200 OK2017-02-21
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200 OK2017-02-14
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200 OK2017-02-07
200 OK2017-02-03
200 OK2017-01-31
200 OK2017-01-27
200 OK2017-01-24
200 OK2017-01-20
-1 Failed2017-01-17
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Tags

Disease Interaction and Network Protein
Homo sapiens
g-quadruplexes ligands

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Jian Sang [2016-09-08]
    • Mengwei Li [2016-02-19]
    • Jian Sang [2015-06-28]
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