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Database Commons - Platinum

Platinum

Citations: 0

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Short name Platinum
Full name Protein-ligand affinity change upon mutation
Description A structural database of experimentally measured effects of mutations on protein-ligand complexes
URL http://bleoberis.bioc.cam.ac.uk/platinum
Year founded 2014
Last update & version 2015-01-01    v1.0
Availability Free to all users
University/Institution hosted University of Cambridge
Address Cambridge CB2 1GA, UK
City Cambridge
Province/State Cambridgeshire
Country/Region United Kingdom
Contact name David B. Ascher
Contact email dascher@svi.edu.au
Data type(s)
Major organism(s)
Keyword(s)
  • non-synonymous single nucleotide polymorphism
  • protein-ligand complex
Publication(s)
  • Platinum: a database of experimentally measured effects of mutations on structurally defined protein-ligand complexes. [PMID: 25324307]

    Douglas E V Pires, Tom L Blundell, David B Ascher
    Nucleic acids research 2015:43(Database issue)
    Citation (to be updated)

    Abstract: Drug resistance is a major challenge for the treatment of many diseases and a significant concern throughout the drug development process. The ability to understand and predict the effects of mutations on protein-ligand affinities and their roles in the emergence of resistance would significantly aid treatment and drug design strategies. In order to study and understand the impacts of missense mutations on the interaction of ligands with the proteome, we have developed Platinum (http://structure.bioc.cam.ac.uk/platinum). This manually curated, literature-derived database, comprising over 1000 mutations, associates for the first time experimental information on changes in affinity with three-dimensional structures of protein-ligand complexes. To minimize differences arising from experimental techniques and to directly compare binding affinities, Platinum considers only changes measured by the same group and with the same amino-acid sequence used for structure determination, providing a direct link between protein structure, how a ligand binds and how mutations alter the affinity of the ligand of the protein. We believe Platinum will be an invaluable resource for understanding the effects of mutations that give rise to drug resistance, a major problem emerging in pandemics including those caused by the influenza virus, in infectious diseases such as tuberculosis, in cancer and in many other life-threatening illnesses. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

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Tags

DNA Protein
Bacteria Homo sapiens Virus
non-synonymous single nucleotide polymorphism protein-ligand complex

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Shixiang Sun [2016-03-25]
    • Shixiang Sun [2015-11-21]
    • Lina Ma [2015-11-18]
    • Lina Ma [2015-11-17]
    • Shixiang Sun [2015-06-28]
    • Shixiang Sun [2015-06-26]
Stats