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Database Commons - SpliceDisease

SpliceDisease

Citations: 27

z-index 0.00

Short name SpliceDisease
Full name
Description Linking RNA splicing and disease
URL http://cmbi.bjmu.edu.cn/sdisease
Year founded 2011
Last update & version 2012-01-01    v1.0
Availability Free to all users
University/Institution hosted Peking University
Address Beijing 100083,China
City Beijing
Province/State
Country/Region China
Contact name Juan Wang
Contact email wjuan@hsc.pku.edu.cn
Data type(s)
Major organism(s)
Keyword(s)
  • RAN splicing
Publication(s)
  • SpliceDisease database: linking RNA splicing and disease. [PMID: 22139928]

    Juan Wang, Jie Zhang, Kaibo Li, Wei Zhao, Qinghua Cui
    Nucleic acids research 2012:40(Database issue)
    27 Citations (Google Scholar as of 2016-01-24)

    Abstract: RNA splicing is an important aspect of gene regulation in many organisms. Splicing of RNA is regulated by complicated mechanisms involving numerous RNA-binding proteins and the intricate network of interactions among them. Mutations in cis-acting splicing elements or its regulatory proteins have been shown to be involved in human diseases. Defects in pre-mRNA splicing process have emerged as a common disease-causing mechanism. Therefore, a database integrating RNA splicing and disease associations would be helpful for understanding not only the RNA splicing but also its contribution to disease. In SpliceDisease database, we manually curated 2337 splicing mutation disease entries involving 303 genes and 370 diseases, which have been supported experimentally in 898 publications. The SpliceDisease database provides information including the change of the nucleotide in the sequence, the location of the mutation on the gene, the reference Pubmed ID and detailed description for the relationship among gene mutations, splicing defects and diseases. We standardized the names of the diseases and genes and provided links for these genes to NCBI and UCSC genome browser for further annotation and genomic sequences. For the location of the mutation, we give direct links of the entry to the respective position/region in the genome browser. The users can freely browse, search and download the data in SpliceDisease at http://cmbi.bjmu.edu.cn/sdisease.

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Tags

Disease RNA
Homo sapiens
RAN splicing

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Lin Xia [2016-03-28]
    • Mengwei Li [2016-02-19]
    • Lin Xia [2015-11-20]
    • Lin Xia [2015-06-28]
Stats