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Database Commons - MethylomeDB

MethylomeDB

Citations: 33

z-index 1.87

Short name MethylomeDB
Full name database containing genome-wide brain DNA methylation profiles
Description MethylomeDB (http://epigenomics.columbia.edu/methylomedb/index.html) is a new database containing genome-wide brain DNA methylation profiles
URL http://epigenomics.columbia.edu/methylomedb/index.html
Year founded 2011
Last update & version 2011-12-02    v1.0
Availability Free to all users
University/Institution hosted Columbia University
Address New York,NY,10032,USA
City New York
Province/State NY
Country/Region United States
Contact name Fatemeh G. Haghighi
Contact email fgh3@columbia.edu
Data type(s)
Major organism(s)
Keyword(s)
  • brain
  • DNA methylation
Publication(s)
  • MethylomeDB: a database of DNA methylation profiles of the brain. [PMID: 22140101]

    Yurong Xin, Benjamin Chanrion, Anne H O'Donnell, Maria Milekic, Ramiro Costa, Yongchao Ge, Fatemeh G Haghighi
    Nucleic acids research 2012:40(Database issue)
    33 Citations (Google Scholar as of 2016-01-28)

    Abstract: MethylomeDB (http://epigenomics.columbia.edu/methylomedb/index.html) is a new database containing genome-wide brain DNA methylation profiles. DNA methylation is an important epigenetic mark in the mammalian brain. In human studies, aberrant DNA methylation alterations have been associated with various neurodevelopmental and neuropsychiatric disorders such as schizophrenia, and depression. In this database, we present methylation profiles of carefully selected non-psychiatric control, schizophrenia, and depression samples. We also include data on one mouse forebrain sample specimen to allow for cross-species comparisons. In addition to our DNA methylation data generated in-house, we have and will continue to include published DNA methylation data from other research groups with the focus on brain development and function. Users can view the methylation data at single-CpG resolution with the option of wiggle and microarray formats. They can also download methylation data for individual samples. MethylomeDB offers an important resource for research into brain function and behavior. It provides the first source of comprehensive brain methylome data, encompassing whole-genome DNA methylation profiles of human and mouse brain specimens that facilitate cross-species comparative epigenomic investigations, as well as investigations of schizophrenia and depression methylomes.

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200 OK2016-01-10
200 OK2016-01-08
200 OK2016-01-06
200 OK2016-01-04

Tags

DNA Modification
Homo sapiens
brain DNA methylation

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Lina Ma [2016-04-14]
    • Lin Liu [2016-03-26]
    • Lina Ma [2015-06-29]
    • Li Yang [2015-06-26]
Stats