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Database Commons - EzCatDB

EzCatDB

Citations: 60

z-index 3.88

Short name EzCatDB
Full name Database of Enzyme Catalytic Mechanisms
Description EzCatDB has emphasized manual classification of enzyme reactions from the viewpoints of enzyme active-site structures and their catalytic mechanisms based on literature information, amino acid sequences of enzymes (UniProtKB) and the corresponding tertiary structures from the Protein Data Bank (PDB).
URL http://ezcatdb.cbrc.jp/EzCatDB/
Year founded 2004
Last update & version NA    v1.0
Availability Free to all users
University/Institution hosted National Institute of Advanced Industrial Science and Technology
Address Computational Biology Research Center (CBRC),National Institute of Advanced Industrial Science and Technology (AIST),Tokyo Waterfront Bio-IT Research Building,2-4-7 Aomi,Koto-ku,Tokyo 135-0064,Japan
City Tokyo
Province/State
Country/Region Japan
Contact name Nozomi Nagano
Contact email n.nagano@aist.go.jp
Data type(s)
Major organism(s)
Keyword(s)
  • enzyme catalytic mechanisms
  • manual curation
  • PDB
  • UniProtKB
Publication(s)
  • EzCatDB: the enzyme reaction database, 2015 update. [PMID: 25324316]

    Nozomi Nagano, Naoko Nakayama, Kazuyoshi Ikeda, Masaru Fukuie, Kiyonobu Yokota, Takuo Doi, Tsuyoshi Kato, Kentaro Tomii
    Nucleic acids research 2015:43(Database issue)
    Citation (to be updated)

    Abstract: The EzCatDB database (http://ezcatdb.cbrc.jp/EzCatDB/) has emphasized manual classification of enzyme reactions from the viewpoints of enzyme active-site structures and their catalytic mechanisms based on literature information, amino acid sequences of enzymes (UniProtKB) and the corresponding tertiary structures from the Protein Data Bank (PDB). Reaction types such as hydrolysis, transfer, addition, elimination, isomerization, hydride transfer and electron transfer have been included in the reaction classification, RLCP. This database includes information related to ligand molecules on the enzyme structures in the PDB data, classified in terms of cofactors, substrates, products and intermediates, which are also necessary to elucidate the catalytic mechanisms. Recently, the database system was updated. The 3D structures of active sites for each PDB entry can be viewed using Jmol or Rasmol software. Moreover, sequence search systems of two types were developed for the EzCatDB database: EzCat-BLAST and EzCat-FORTE. EzCat-BLAST is suitable for quick searches, adopting the BLAST algorithm, whereas EzCat-FORTE is more suitable for detecting remote homologues, adopting the algorithm for FORTE protein structure prediction software. Another system, EzMetAct, is also available to searching for major active-site structures in EzCatDB, for which PDB-formatted queries can be searched. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  • EzCatDB: the Enzyme Catalytic-mechanism Database. [PMID: 15608227]

    Nozomi Nagano
    Nucleic acids research 2005:33(Database issue)
    60 Citations (Google Scholar as of 2016-01-24)

    Abstract: The EzCatDB (Enzyme Catalytic-mechanism Database) specifically includes catalytic mechanisms of enzymes in terms of sequences and tertiary structures of enzymes, and proposed catalytic mechanisms, along with ligand structures. The EzCatDB groups enzyme data in the Protein Data Bank (PDB) and the SWISS-PROT database with identical domain compositions, Enzyme Commission (EC) numbers and catalytic mechanisms. The EzCatDB can be queried by the type of catalytic residue, name and type of ligand molecule that interacts with an enzyme as a cofactor, substrate or product. It can provide literature information, other database codes and EC numbers. The EzCatDB provides ligand annotation for enzymes in the PDB as well as literature information on structure and catalytic mechanisms. Furthermore, the EzCatDB also provides a hierarchic classification of catalytic mechanisms. This classification incorporates catalytic mechanisms and active-site structures of enzymes as well as basic reactions and reactive parts of ligand molecules. The EzCatDB is available at http://mbs.cbrc.jp/EzCatDB/.

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Accessibility

Rate of accessibility:
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200 OK2018-10-02
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200 OK2018-05-25
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200 OK2018-05-15
200 OK2018-05-11
200 OK2018-05-08
200 OK2018-05-04
200 OK2018-05-01
200 OK2018-04-27
200 OK2018-04-24
200 OK2018-04-20
200 OK2018-04-17
200 OK2018-04-13
200 OK2018-04-10
200 OK2018-04-06
200 OK2018-04-03
200 OK2018-02-27
200 OK2018-02-23
200 OK2018-02-20
200 OK2018-02-16
200 OK2018-02-13
200 OK2018-02-09
200 OK2018-02-06
200 OK2018-02-02
200 OK2018-01-30
200 OK2018-01-26
200 OK2018-01-23
200 OK2018-01-19
200 OK2018-01-16
200 OK2018-01-12
200 OK2018-01-09
200 OK2018-01-05
200 OK2018-01-02
200 OK2017-12-29
200 OK2017-12-26
200 OK2017-12-22
200 OK2017-12-19
200 OK2017-12-15
200 OK2017-12-12
200 OK2017-12-08
200 OK2017-12-05
200 OK2017-12-01
200 OK2017-11-28
200 OK2017-11-24
200 OK2017-11-21
200 OK2017-11-17
200 OK2017-11-14
200 OK2017-11-10
200 OK2017-11-07
200 OK2017-11-03
200 OK2017-10-31
200 OK2017-10-27
200 OK2017-10-24
200 OK2017-10-20
200 OK2017-10-17
200 OK2017-10-13
200 OK2017-10-10
200 OK2017-10-06
200 OK2017-10-03
200 OK2017-09-29
200 OK2017-09-26
200 OK2017-09-22
200 OK2017-09-19
200 OK2017-09-15
200 OK2017-09-12
200 OK2017-09-08
200 OK2017-09-05
200 OK2017-09-01
200 OK2017-08-29
200 OK2017-08-25
200 OK2017-08-22
200 OK2017-08-18
200 OK2017-08-15
200 OK2017-08-11
200 OK2017-08-08
200 OK2017-08-04
200 OK2017-08-01
200 OK2017-07-28
200 OK2017-07-25
200 OK2017-07-21
200 OK2017-07-18
200 OK2017-07-14
200 OK2017-07-04
200 OK2017-06-30
200 OK2017-06-27
200 OK2017-06-23
200 OK2017-06-20
200 OK2017-06-16
200 OK2017-06-13
200 OK2017-06-09
200 OK2017-06-06
200 OK2017-06-02
200 OK2017-05-30
200 OK2017-05-26
200 OK2017-05-23
200 OK2017-05-19
200 OK2017-05-16
200 OK2017-05-12
200 OK2017-05-09
200 OK2017-05-05
200 OK2017-05-02
200 OK2017-04-28
200 OK2017-04-25
200 OK2017-04-21
200 OK2017-04-18
200 OK2017-04-14
200 OK2017-04-11
200 OK2017-04-07
200 OK2017-04-04
200 OK2017-03-31
200 OK2017-03-28
200 OK2017-03-24
200 OK2017-03-21
200 OK2017-03-17
200 OK2017-03-14
200 OK2017-03-10
200 OK2017-03-07
200 OK2017-03-03
200 OK2017-02-28
200 OK2017-02-24
200 OK2017-02-21
200 OK2017-02-17
200 OK2017-02-14
200 OK2017-02-10
200 OK2017-02-07
200 OK2017-02-03
200 OK2017-01-31
200 OK2017-01-27
200 OK2017-01-24
200 OK2017-01-20
200 OK2017-01-17
200 OK2017-01-13
200 OK2017-01-10
200 OK2017-01-06
200 OK2017-01-03
200 OK2016-12-30
200 OK2016-12-27
200 OK2016-12-23
200 OK2016-12-20
200 OK2016-12-16
200 OK2016-12-13
-1 Failed2016-12-09
-1 Failed2016-12-06
200 OK2016-12-02
200 OK2016-11-29
200 OK2016-11-25
200 OK2016-11-22
200 OK2016-11-18
200 OK2016-11-15
200 OK2016-11-11
200 OK2016-11-08
200 OK2016-11-04
200 OK2016-11-01
200 OK2016-10-28
200 OK2016-10-25
200 OK2016-10-21
200 OK2016-10-18
200 OK2016-10-14
200 OK2016-10-11
200 OK2016-10-07
200 OK2016-10-04
200 OK2016-09-30
200 OK2016-09-27
200 OK2016-09-23
200 OK2016-09-20
200 OK2016-09-16
200 OK2016-09-13
200 OK2016-09-09
200 OK2016-09-06
200 OK2016-09-02
200 OK2016-08-30
200 OK2016-08-26
200 OK2016-08-23
200 OK2016-08-19
200 OK2016-08-16
200 OK2016-08-12
200 OK2016-08-09
200 OK2016-08-05
200 OK2016-08-02
200 OK2016-07-29
200 OK2016-07-26
200 OK2016-07-22
200 OK2016-07-19
200 OK2016-07-15
200 OK2016-07-12
200 OK2016-07-08
200 OK2016-07-05
200 OK2016-07-01
200 OK2016-06-28
200 OK2016-06-24
200 OK2016-06-21
200 OK2016-06-17
200 OK2016-06-14
200 OK2016-06-10
200 OK2016-06-07
200 OK2016-06-03
200 OK2016-05-31
503 Failed2016-05-27
200 OK2016-05-24
200 OK2016-05-20
200 OK2016-05-17
200 OK2016-05-13
200 OK2016-05-10
200 OK2016-05-06
200 OK2016-05-03
200 OK2016-04-29
200 OK2016-04-26
200 OK2016-04-22
200 OK2016-04-19
200 OK2016-04-15
200 OK2016-04-12
200 OK2016-04-08
200 OK2016-04-05
200 OK2016-04-01
-1 Failed2016-03-29
-1 Failed2016-03-28
-1 Failed2016-03-25
-1 Failed2016-03-23
-1 Failed2016-03-21
-1 Failed2016-03-18
-1 Failed2016-03-16
-1 Failed2016-03-14
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-1 Failed2016-02-29
-1 Failed2016-02-26
-1 Failed2016-02-24
-1 Failed2016-02-22
-1 Failed2016-02-19
-1 Failed2016-02-17
-1 Failed2016-02-15
-1 Failed2016-02-14
-1 Failed2016-02-12
-1 Failed2016-02-10
-1 Failed2016-02-08
-1 Failed2016-02-07
-1 Failed2016-02-05
-1 Failed2016-02-03
-1 Failed2016-02-01
-1 Failed2016-01-31
-1 Failed2016-01-29
-1 Failed2016-01-27
-1 Failed2016-01-25
-1 Failed2016-01-24
-1 Failed2016-01-22
-1 Failed2016-01-20
-1 Failed2016-01-18
-1 Failed2016-01-17
-1 Failed2016-01-15
-1 Failed2016-01-13
-1 Failed2016-01-11
-1 Failed2016-01-10
-1 Failed2016-01-08
-1 Failed2016-01-06
-1 Failed2016-01-04

Tags

Protein Standard, Ontology and Nomenclature
enzyme catalytic mechanisms manual curation PDB UniProtKB

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Jian Sang [2016-04-05]
    • Mengwei Li [2016-02-18]
    • Jian Sang [2015-06-28]
    • Jian Sang [2015-06-27]
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