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Database Commons - dbCRID

dbCRID

Citations: 23

z-index 0.46

Short name dbCRID
Full name Chromosomal Rearrangements In Diseases
Description dbCRID is a comprehensive and dynamic resource useful for studying DNA breakage and repair mechanisms, and for analyzing the genetic basis of human tumor and non-tumor diseases
URL http://dbcrid.biolead.org/
Year founded 2010
Last update & version NA    v1.0
Availability Free to all users
University/Institution hosted LC Sciences
Address Biolead.org Research Group,LC Sciences,Houston,TX 77054,USA
City Houston
Province/State TX
Country/Region United States
Contact name Tongbin Li
Contact email toli@biolead.org
Data type(s)
Major organism(s)
Keyword(s)
  • Chromosomal rearrangement (CR)
  • DNA breakage and repair
  • tumor and non-tumor diseases
Publication(s)
  • dbCRID: a database of chromosomal rearrangements in human diseases. [PMID: 21051346]

    Fanlou Kong, Jing Zhu, Jun Wu, Jianjian Peng, Ying Wang, Qing Wang, Songbin Fu, Li-Lian Yuan, Tongbin Li
    Nucleic acids research 2011:39(Database issue)
    23 Citations (Google Scholar as of 2016-05-03)

    Abstract: Chromosomal rearrangement (CR) events result from abnormal breaking and rejoining of the DNA molecules, or from crossing-over between repetitive DNA sequences, and they are involved in many tumor and non-tumor diseases. Investigations of disease-associated CR events can not only lead to important discoveries about DNA breakage and repair mechanisms, but also offer important clues about the pathologic causes and the diagnostic/therapeutic targets of these diseases. We have developed a database of Chromosomal Rearrangements In Diseases (dbCRID, http://dbCRID.biolead.org), a comprehensive database of human CR events and their associated diseases. For each reported CR event, dbCRID documents the type of the event, the disease or symptoms associated, and--when possible--detailed information about the CR event including precise breakpoint positions, junction sequences, genes and gene regions disrupted and experimental techniques applied to discover/analyze the CR event. With 2643 records of disease-associated CR events curated from 1172 original studies, dbCRID is a comprehensive and dynamic resource useful for studying DNA breakage and repair mechanisms, and for analyzing the genetic basis of human tumor and non-tumor diseases.

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Tags

Disease DNA
Homo sapiens
Chromosomal rearrangement (CR) DNA breakage and repair tumor and non-tumor diseases

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Jian Sang [2016-04-04]
    • Jian Sang [2015-12-01]
    • Lina Ma [2015-11-25]
    • Jian Sang [2015-06-26]
Stats