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Database Commons - RAC

RAC

Citations: 15

z-index 0.00

Short name RAC
Full name Repository of Antibiotic
Description RAC provides a unique resource for researchers, which should reduce confusion and improve the quality of annotations of gene cassettes in integrons associated with antibiotic resistance
URL http://www2.chi.unsw.edu.au/rac
Year founded 2011
Last update & version 2011-12-07    V1.0
Availability Not Available
University/Institution hosted University of New South Wales
Address Mathews Building F23, Level 2 (Pavilions Level) Botany Street, Gate 11 Kensington 2033
City Sydney
Province/State
Country/Region Australia
Contact name Guy Tsafnat
Contact email guyt@unsw.edu.au
Data type(s)
Major organism(s)
Keyword(s)
  • Antibiotic resistance
  • gene annotation
Publication(s)
  • RAC: Repository of Antibiotic resistance Cassettes. [PMID: 22140215]

    Guy Tsafnat, Joseph Copty, Sally R Partridge
    Database : the journal of biological databases and curation 2011:2011
    15 Citations (Google Scholar as of 2016-01-19)

    Abstract: Antibiotic resistance in bacteria is often due to acquisition of resistance genes associated with different mobile genetic elements. In Gram-negative bacteria, many resistance genes are found as part of small mobile genetic elements called gene cassettes, generally found integrated into larger elements called integrons. Integrons carrying antibiotic resistance gene cassettes are often associated with mobile elements and here are designated 'mobile resistance integrons' (MRIs). More than one cassette can be inserted in the same integron to create arrays that contribute to the spread of multi-resistance. In many sequences in databases such as GenBank, only the genes within cassettes, rather than whole cassettes, are annotated and the same gene/cassette may be given different names in different entries, hampering analysis. We have developed the Repository of Antibiotic resistance Cassettes (RAC) website to provide an archive of gene cassettes that includes alternative gene names from multiple nomenclature systems and allows the community to contribute new cassettes. RAC also offers an additional function that allows users to submit sequences containing cassettes or arrays for annotation using the automatic annotation system Attacca. Attacca recognizes features (gene cassettes, integron regions) and identifies cassette arrays as patterns of features and can also distinguish minor cassette variants that may encode different resistance phenotypes (aacA4 cassettes and bla cassettes-encoding ?-lactamases). Gaps in annotations are manually reviewed and those found to correspond to novel cassettes are assigned unique names. While there are other websites dedicated to integrons or antibiotic resistance genes, none includes a complete list of antibiotic resistance gene cassettes in MRI or offers consistent annotation and appropriate naming of all of these cassettes in submitted sequences. RAC thus provides a unique resource for researchers, which should reduce confusion and improve the quality of annotations of gene cassettes in integrons associated with antibiotic resistance. DATABASE URL: http://www2.chi.unsw.edu.au/rac.

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Tags

DNA
Bacteria
Antibiotic resistance gene annotation

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Lin Xia [2016-03-28]
    • Lin Xia [2015-06-26]
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