Database Commons a catalog of biological databases

Database Commons - MuteinDB

MuteinDB

Citations: 4

z-index 0.00

Short name MuteinDB
Full name The Mutein Database
Description The mutein database linking substrates,products and enzymatic reactions directly with genetic variants of enzymes
URL http://www.muteindb.org/
Year founded 2012
Last update & version 2012-06-21    V1.0
Availability Not Available
University/Institution hosted Graz University of Technology
Address 8010 Graz, Austria
City Graz
Province/State
Country/Region Austria
Contact name Gerhard G. Thallinger
Contact email Gerhard.Thallinger@tugraz.at
Data type(s)
Major organism(s)
Keyword(s)
  • variant of enzyme
Publication(s)
  • MuteinDB: the mutein database linking substrates, products and enzymatic reactions directly with genetic variants of enzymes. [PMID: 22730453]

    Andreas Braun, Bettina Halwachs, Martina Geier, Katrin Weinhandl, Michael Guggemos, Jan Marienhagen, Anna J Ruff, Ulrich Schwaneberg, Vincent Rabin, Daniel E Torres PazmiƱo, Gerhard G Thallinger, Anton Glieder
    Database : the journal of biological databases and curation 2012:2012
    4 Citations (Google Scholar as of 2016-01-26)

    Abstract: Mutational events as well as the selection of the optimal variant are essential steps in the evolution of living organisms. The same principle is used in laboratory to extend the natural biodiversity to obtain better catalysts for applications in biomanufacturing or for improved biopharmaceuticals. Furthermore, single mutation in genes of drug-metabolizing enzymes can also result in dramatic changes in pharmacokinetics. These changes are a major cause of patient-specific drug responses and are, therefore, the molecular basis for personalized medicine. MuteinDB systematically links laboratory-generated enzyme variants (muteins) and natural isoforms with their biochemical properties including kinetic data of catalyzed reactions. Detailed information about kinetic characteristics of muteins is available in a systematic way and searchable for known mutations and catalyzed reactions as well as their substrates and known products. MuteinDB is broadly applicable to any known protein and their variants and makes mutagenesis and biochemical data searchable and comparable in a simple and easy-to-use manner. For the import of new mutein data, a simple, standardized, spreadsheet-based data format has been defined. To demonstrate the broad applicability of the MuteinDB, first data sets have been incorporated for selected cytochrome P450 enzymes as well as for nitrilases and peroxidases. Database URL: http://www.MuteinDB.org.

Community reviews

Data
quality & quantity
Content organization & presentation
System accessibility & reliability
Reviewed by

Word cloud (embeddable)

Database Commons - Word Cloud

Accessibility

Rate of accessibility:
HTTP status codeDate requested
-1 Failed2018-11-20
-1 Failed2018-11-16
-1 Failed2018-11-13
-1 Failed2018-11-09
-1 Failed2018-11-06
-1 Failed2018-11-02
-1 Failed2018-10-30
-1 Failed2018-10-26
-1 Failed2018-10-23
-1 Failed2018-10-19
-1 Failed2018-10-16
-1 Failed2018-10-12
-1 Failed2018-10-09
-1 Failed2018-10-05
-1 Failed2018-10-02
-1 Failed2018-09-28
-1 Failed2018-09-25
-1 Failed2018-09-21
-1 Failed2018-09-18
-1 Failed2018-09-14
-1 Failed2018-09-11
-1 Failed2018-09-07
-1 Failed2018-09-04
-1 Failed2018-08-31
-1 Failed2018-08-28
-1 Failed2018-08-24
-1 Failed2018-08-21
-1 Failed2018-08-17
-1 Failed2018-08-14
-1 Failed2018-08-10
-1 Failed2018-08-07
-1 Failed2018-08-03
-1 Failed2018-07-31
-1 Failed2018-07-27
-1 Failed2018-07-24
-1 Failed2018-07-20
-1 Failed2018-07-17
-1 Failed2018-07-13
-1 Failed2018-07-10
-1 Failed2018-07-06
-1 Failed2018-07-03
-1 Failed2018-06-29
-1 Failed2018-06-26
-1 Failed2018-06-22
-1 Failed2018-06-19
-1 Failed2018-06-15
-1 Failed2018-06-12
-1 Failed2018-06-08
-1 Failed2018-06-05
-1 Failed2018-06-01
-1 Failed2018-05-29
-1 Failed2018-05-25
-1 Failed2018-05-22
-1 Failed2018-05-18
-1 Failed2018-05-15
-1 Failed2018-05-11
-1 Failed2018-05-08
-1 Failed2018-05-04
-1 Failed2018-05-01
-1 Failed2018-04-27
-1 Failed2018-04-24
-1 Failed2018-04-20
-1 Failed2018-04-17
-1 Failed2018-04-13
-1 Failed2018-04-10
-1 Failed2018-04-06
-1 Failed2018-04-03
-1 Failed2018-02-27
-1 Failed2018-02-23
-1 Failed2018-02-20
-1 Failed2018-02-16
-1 Failed2018-02-13
-1 Failed2018-02-09
-1 Failed2018-02-06
-1 Failed2018-02-02
-1 Failed2018-01-30
-1 Failed2018-01-26
-1 Failed2018-01-23
-1 Failed2018-01-19
-1 Failed2018-01-16
-1 Failed2018-01-12
-1 Failed2018-01-09
-1 Failed2018-01-05
-1 Failed2018-01-02
-1 Failed2017-12-29
-1 Failed2017-12-26
-1 Failed2017-12-22
-1 Failed2017-12-19
-1 Failed2017-12-15
-1 Failed2017-12-12
-1 Failed2017-12-08
-1 Failed2017-12-05
-1 Failed2017-12-01
-1 Failed2017-11-28
-1 Failed2017-11-24
-1 Failed2017-11-21
-1 Failed2017-11-17
-1 Failed2017-11-14
-1 Failed2017-11-10
-1 Failed2017-11-07
-1 Failed2017-11-03
-1 Failed2017-10-31
-1 Failed2017-10-27
-1 Failed2017-10-24
-1 Failed2017-10-20
-1 Failed2017-10-17
-1 Failed2017-10-13
-1 Failed2017-10-10
-1 Failed2017-10-06
-1 Failed2017-10-03
-1 Failed2017-09-29
-1 Failed2017-09-26
-1 Failed2017-09-22
-1 Failed2017-09-19
-1 Failed2017-09-15
-1 Failed2017-09-12
-1 Failed2017-09-08
-1 Failed2017-09-05
-1 Failed2017-09-01
-1 Failed2017-08-29
-1 Failed2017-08-25
-1 Failed2017-08-22
-1 Failed2017-08-18
-1 Failed2017-08-15
-1 Failed2017-08-11
-1 Failed2017-08-08
-1 Failed2017-08-04
-1 Failed2017-08-01
-1 Failed2017-07-28
-1 Failed2017-07-25
-1 Failed2017-07-21
-1 Failed2017-07-18
-1 Failed2017-07-14
-1 Failed2017-07-04
-1 Failed2017-06-30
-1 Failed2017-06-27
-1 Failed2017-06-23
-1 Failed2017-06-20
-1 Failed2017-06-16
-1 Failed2017-06-13
-1 Failed2017-06-09
-1 Failed2017-06-06
-1 Failed2017-06-02
-1 Failed2017-05-30
-1 Failed2017-05-26
-1 Failed2017-05-23
-1 Failed2017-05-19
-1 Failed2017-05-16
-1 Failed2017-05-12
-1 Failed2017-05-09
-1 Failed2017-05-05
-1 Failed2017-05-02
-1 Failed2017-04-28
-1 Failed2017-04-25
-1 Failed2017-04-21
-1 Failed2017-04-18
-1 Failed2017-04-14
-1 Failed2017-04-11
-1 Failed2017-04-07
-1 Failed2017-04-04
-1 Failed2017-03-31
-1 Failed2017-03-28
-1 Failed2017-03-24
-1 Failed2017-03-21
-1 Failed2017-03-17
-1 Failed2017-03-14
-1 Failed2017-03-10
-1 Failed2017-03-07
-1 Failed2017-03-03
-1 Failed2017-02-28
-1 Failed2017-02-24
-1 Failed2017-02-21
-1 Failed2017-02-17
-1 Failed2017-02-14
-1 Failed2017-02-10
-1 Failed2017-02-07
-1 Failed2017-02-03
-1 Failed2017-01-31
-1 Failed2017-01-27
-1 Failed2017-01-24
-1 Failed2017-01-20
-1 Failed2017-01-17
-1 Failed2017-01-13
-1 Failed2017-01-10
-1 Failed2017-01-06
-1 Failed2017-01-03
-1 Failed2016-12-30
-1 Failed2016-12-27
-1 Failed2016-12-23
-1 Failed2016-12-20
-1 Failed2016-12-16
-1 Failed2016-12-13
-1 Failed2016-12-09
-1 Failed2016-12-06
-1 Failed2016-12-02
-1 Failed2016-11-29
-1 Failed2016-11-25
-1 Failed2016-11-22
-1 Failed2016-11-18
-1 Failed2016-11-15
-1 Failed2016-11-11
-1 Failed2016-11-08
-1 Failed2016-11-04
-1 Failed2016-11-01
-1 Failed2016-10-28
-1 Failed2016-10-25
-1 Failed2016-10-21
-1 Failed2016-10-18
-1 Failed2016-10-14
-1 Failed2016-10-11
-1 Failed2016-10-07
-1 Failed2016-10-04
-1 Failed2016-09-30
-1 Failed2016-09-27
-1 Failed2016-09-23
-1 Failed2016-09-20
-1 Failed2016-09-16
-1 Failed2016-09-13
-1 Failed2016-09-09
-1 Failed2016-09-06
-1 Failed2016-09-02
-1 Failed2016-08-30
-1 Failed2016-08-26
-1 Failed2016-08-23
-1 Failed2016-08-19
-1 Failed2016-08-16
-1 Failed2016-08-12
-1 Failed2016-08-09
-1 Failed2016-08-05
-1 Failed2016-08-02
-1 Failed2016-07-29
-1 Failed2016-07-26
-1 Failed2016-07-22
-1 Failed2016-07-19
-1 Failed2016-07-15
-1 Failed2016-07-12
-1 Failed2016-07-08
-1 Failed2016-07-05
-1 Failed2016-07-01
-1 Failed2016-06-28
-1 Failed2016-06-24
-1 Failed2016-06-21
-1 Failed2016-06-17
-1 Failed2016-06-14
-1 Failed2016-06-10
-1 Failed2016-06-07
-1 Failed2016-06-03
-1 Failed2016-05-31
-1 Failed2016-05-27
-1 Failed2016-05-24
-1 Failed2016-05-20
-1 Failed2016-05-17
-1 Failed2016-05-13
-1 Failed2016-05-10
-1 Failed2016-05-06
-1 Failed2016-05-03
-1 Failed2016-04-29
-1 Failed2016-04-26
-1 Failed2016-04-22
-1 Failed2016-04-19
-1 Failed2016-04-15
-1 Failed2016-04-12
-1 Failed2016-04-08
-1 Failed2016-04-05
-1 Failed2016-04-01
-1 Failed2016-03-29
-1 Failed2016-03-28
-1 Failed2016-03-25
-1 Failed2016-03-23
-1 Failed2016-03-21
-1 Failed2016-03-18
-1 Failed2016-03-16
-1 Failed2016-03-14
-1 Failed2016-03-11
-1 Failed2016-03-09
-1 Failed2016-03-07
-1 Failed2016-03-04
-1 Failed2016-03-02
-1 Failed2016-02-29
-1 Failed2016-02-26
-1 Failed2016-02-24
-1 Failed2016-02-22
-1 Failed2016-02-19
-1 Failed2016-02-17
-1 Failed2016-02-15
-1 Failed2016-02-14
-1 Failed2016-02-12
-1 Failed2016-02-10
-1 Failed2016-02-08
-1 Failed2016-02-07
-1 Failed2016-02-05
-1 Failed2016-02-03
-1 Failed2016-02-01
-1 Failed2016-01-31
-1 Failed2016-01-29
-1 Failed2016-01-27
-1 Failed2016-01-25
-1 Failed2016-01-24
-1 Failed2016-01-22
-1 Failed2016-01-20
-1 Failed2016-01-18
-1 Failed2016-01-17
-1 Failed2016-01-15
-1 Failed2016-01-13
-1 Failed2016-01-11
-1 Failed2016-01-10
-1 Failed2016-01-08
-1 Failed2016-01-06
-1 Failed2016-01-04

Tags

DNA Drug and Chemical Compound Protein
variant of enzyme

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Lin Liu [2016-03-27]
    • Mengwei Li [2016-02-07]
    • Li Yang [2015-06-26]
Stats