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Database Commons - Dr. PIAS

Dr. PIAS

Citations: 28

z-index 3.24

Short name Dr. PIAS
Full name Druggable Protein-protein Interaction Assessment System
Description Druggable Protein-protein Interaction Assessment System (Dr. PIAS) is a database of druggable protein-protein interactions (PPIs) predicted by our support vector machine (SVM)-based method.
URL http://www.drpias.net
Year founded 2011
Last update & version NA    V2.0
Availability Not Available
University/Institution hosted PharmaDesign,Inc.
Address Hatchobori 2-19-8,Chuo-ku,Tokyo 104-0032,Japan
City Tokyo
Province/State
Country/Region Japan
Contact name Nobuyoshi Sugaya
Contact email sugaya@pharmadesign.co.jp
Data type(s)
Major organism(s)
Keyword(s)
  • protein-protein interaction
  • SVM
Publication(s)
  • Dr. PIAS 2.0: an update of a database of predicted druggable protein-protein interactions. [PMID: 23060433]

    Nobuyoshi Sugaya, Satoru Kanai, Toshio Furuya
    Database : the journal of biological databases and curation 2012:2012
    10 Citations (Google Scholar as of 2016-01-27)

    Abstract: Druggable Protein-protein Interaction Assessment System (Dr. PIAS) is a database of druggable protein-protein interactions (PPIs) predicted by our support vector machine (SVM)-based method. Since the first publication of this database, Dr. PIAS has been updated to version 2.0. PPI data have been increased considerably, from 71,500 to 83,324 entries. As the new positive instances in our method, 4 PPIs and 10 tertiary structures have been added. This addition increases the prediction accuracy of our SVM classifier in comparison with the previous classifier, despite the number of added PPIs and structures is small. We have introduced the novel concept of 'similar positives' of druggable PPIs, which will help researchers discover small compounds that can inhibit predicted druggable PPIs. Dr. PIAS will aid the effective search for druggable PPIs from a mine of interactome data being rapidly accumulated. Dr. PIAS 2.0 is available at http://www.drpias.net.

  • Dr. PIAS: an integrative system for assessing the druggability of protein-protein interactions. [PMID: 21303559]

    Nobuyoshi Sugaya, Toshio Furuya
    BMC bioinformatics 2011:12
    18 Citations (Google Scholar as of 2016-01-27)

    Abstract: The amount of data on protein-protein interactions (PPIs) available in public databases and in the literature has rapidly expanded in recent years. PPI data can provide useful information for researchers in pharmacology and medicine as well as those in interactome studies. There is urgent need for a novel methodology or software allowing the efficient utilization of PPI data in pharmacology and medicine. To address this need, we have developed the 'Druggable Protein-protein Interaction Assessment System' (Dr. PIAS). Dr. PIAS has a meta-database that stores various types of information (tertiary structures, drugs/chemicals, and biological functions associated with PPIs) retrieved from public sources. By integrating this information, Dr. PIAS assesses whether a PPI is druggable as a target for small chemical ligands by using a supervised machine-learning method, support vector machine (SVM). Dr. PIAS holds not only known druggable PPIs but also all PPIs of human, mouse, rat, and human immunodeficiency virus (HIV) proteins identified to date. The design concept of Dr. PIAS is distinct from other published PPI databases in that it focuses on selecting the PPIs most likely to make good drug targets, rather than merely collecting PPI data.

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Accessibility

Rate of accessibility:
HTTP status codeDate requested
200 OK2018-11-20
200 OK2018-11-16
200 OK2018-11-13
200 OK2018-11-09
200 OK2018-11-06
200 OK2018-11-02
200 OK2018-10-30
200 OK2018-10-26
200 OK2018-10-23
200 OK2018-10-19
200 OK2018-10-16
200 OK2018-10-12
200 OK2018-10-09
200 OK2018-10-05
200 OK2018-10-02
200 OK2018-09-28
200 OK2018-09-25
200 OK2018-09-21
200 OK2018-09-18
200 OK2018-09-14
200 OK2018-09-11
200 OK2018-09-07
200 OK2018-09-04
200 OK2018-08-31
200 OK2018-08-28
200 OK2018-08-24
200 OK2018-08-21
200 OK2018-08-17
200 OK2018-08-14
200 OK2018-08-10
200 OK2018-08-07
200 OK2018-08-03
200 OK2018-07-31
200 OK2018-07-27
200 OK2018-07-24
200 OK2018-07-20
200 OK2018-07-17
200 OK2018-07-13
200 OK2018-07-10
200 OK2018-07-06
200 OK2018-07-03
200 OK2018-06-29
200 OK2018-06-26
200 OK2018-06-22
200 OK2018-06-19
200 OK2018-06-15
200 OK2018-06-12
200 OK2018-06-08
200 OK2018-06-05
200 OK2018-06-01
200 OK2018-05-29
200 OK2018-05-25
200 OK2018-05-22
200 OK2018-05-18
200 OK2018-05-15
200 OK2018-05-11
200 OK2018-05-08
200 OK2018-05-04
200 OK2018-05-01
200 OK2018-04-27
200 OK2018-04-24
200 OK2018-04-20
200 OK2018-04-17
200 OK2018-04-13
200 OK2018-04-10
200 OK2018-04-06
200 OK2018-04-03
200 OK2018-02-27
200 OK2018-02-23
200 OK2018-02-20
200 OK2018-02-16
200 OK2018-02-13
200 OK2018-02-09
200 OK2018-02-06
200 OK2018-02-02
200 OK2018-01-30
200 OK2018-01-26
200 OK2018-01-23
200 OK2018-01-19
200 OK2018-01-16
200 OK2018-01-12
200 OK2018-01-09
200 OK2018-01-05
200 OK2018-01-02
200 OK2017-12-29
200 OK2017-12-26
200 OK2017-12-22
200 OK2017-12-19
200 OK2017-12-15
200 OK2017-12-12
200 OK2017-12-08
200 OK2017-12-05
200 OK2017-12-01
200 OK2017-11-28
200 OK2017-11-24
200 OK2017-11-21
200 OK2017-11-17
200 OK2017-11-14
200 OK2017-11-10
200 OK2017-11-07
200 OK2017-11-03
200 OK2017-10-31
200 OK2017-10-27
200 OK2017-10-24
200 OK2017-10-20
200 OK2017-10-17
200 OK2017-10-13
200 OK2017-10-10
200 OK2017-10-06
200 OK2017-10-03
200 OK2017-09-29
200 OK2017-09-26
200 OK2017-09-22
200 OK2017-09-19
200 OK2017-09-15
200 OK2017-09-12
200 OK2017-09-08
200 OK2017-09-05
200 OK2017-09-01
200 OK2017-08-29
200 OK2017-08-25
200 OK2017-08-22
200 OK2017-08-18
200 OK2017-08-15
200 OK2017-08-11
200 OK2017-08-08
200 OK2017-08-04
200 OK2017-08-01
200 OK2017-07-28
200 OK2017-07-25
200 OK2017-07-21
200 OK2017-07-18
200 OK2017-07-14
200 OK2017-07-04
200 OK2017-06-30
200 OK2017-06-27
200 OK2017-06-23
200 OK2017-06-20
200 OK2017-06-16
200 OK2017-06-13
200 OK2017-06-09
200 OK2017-06-06
200 OK2017-06-02
200 OK2017-05-30
200 OK2017-05-26
200 OK2017-05-23
200 OK2017-05-19
200 OK2017-05-16
200 OK2017-05-12
200 OK2017-05-09
200 OK2017-05-05
200 OK2017-05-02
200 OK2017-04-28
200 OK2017-04-25
200 OK2017-04-21
200 OK2017-04-18
200 OK2017-04-14
200 OK2017-04-11
200 OK2017-04-07
200 OK2017-04-04
200 OK2017-03-31
200 OK2017-03-28
-1 Failed2017-03-24
200 OK2017-03-21
200 OK2017-03-17
200 OK2017-03-14
200 OK2017-03-10
200 OK2017-03-07
200 OK2017-03-03
200 OK2017-02-28
200 OK2017-02-24
200 OK2017-02-21
200 OK2017-02-17
200 OK2017-02-14
200 OK2017-02-10
200 OK2017-02-07
200 OK2017-02-03
200 OK2017-01-31
200 OK2017-01-27
200 OK2017-01-24
200 OK2017-01-20
200 OK2017-01-17
200 OK2017-01-13
200 OK2017-01-10
200 OK2017-01-06
200 OK2017-01-03
200 OK2016-12-30
200 OK2016-12-27
200 OK2016-12-23
200 OK2016-12-20
200 OK2016-12-16
200 OK2016-12-13
200 OK2016-12-09
200 OK2016-12-06
200 OK2016-12-02
200 OK2016-11-29
200 OK2016-11-25
200 OK2016-11-22
200 OK2016-11-18
200 OK2016-11-15
200 OK2016-11-11
200 OK2016-11-08
200 OK2016-11-04
200 OK2016-11-01
200 OK2016-10-28
200 OK2016-10-25
200 OK2016-10-21
200 OK2016-10-18
200 OK2016-10-14
200 OK2016-10-11
200 OK2016-10-07
200 OK2016-10-04
200 OK2016-09-30
200 OK2016-09-27
200 OK2016-09-23
200 OK2016-09-20
200 OK2016-09-16
200 OK2016-09-13
200 OK2016-09-09
200 OK2016-09-06
200 OK2016-09-02
200 OK2016-08-30
200 OK2016-08-26
200 OK2016-08-23
200 OK2016-08-19
200 OK2016-08-16
200 OK2016-08-12
200 OK2016-08-09
200 OK2016-08-05
200 OK2016-08-02
200 OK2016-07-29
200 OK2016-07-26
200 OK2016-07-22
200 OK2016-07-19
200 OK2016-07-15
200 OK2016-07-12
200 OK2016-07-08
200 OK2016-07-05
200 OK2016-07-01
200 OK2016-06-28
200 OK2016-06-24
200 OK2016-06-21
200 OK2016-06-17
200 OK2016-06-14
200 OK2016-06-10
200 OK2016-06-07
200 OK2016-06-03
200 OK2016-05-31
200 OK2016-05-27
200 OK2016-05-24
-1 Failed2016-05-20
-1 Failed2016-05-17
-1 Failed2016-05-13
-1 Failed2016-05-10
-1 Failed2016-05-06
-1 Failed2016-05-03
-1 Failed2016-04-29
-1 Failed2016-04-26
-1 Failed2016-04-22
-1 Failed2016-04-19
-1 Failed2016-04-15
-1 Failed2016-04-12
-1 Failed2016-04-08
-1 Failed2016-04-05
-1 Failed2016-04-01
-1 Failed2016-03-29
-1 Failed2016-03-28
-1 Failed2016-03-25
-1 Failed2016-03-23
-1 Failed2016-03-21
-1 Failed2016-03-18
-1 Failed2016-03-16
-1 Failed2016-03-14
-1 Failed2016-03-11
-1 Failed2016-03-09
-1 Failed2016-03-07
-1 Failed2016-03-04
-1 Failed2016-03-02
-1 Failed2016-02-29
-1 Failed2016-02-26
-1 Failed2016-02-24
-1 Failed2016-02-22
-1 Failed2016-02-19
-1 Failed2016-02-17
-1 Failed2016-02-15
-1 Failed2016-02-14
-1 Failed2016-02-12
-1 Failed2016-02-10
-1 Failed2016-02-08
-1 Failed2016-02-07
-1 Failed2016-02-05
-1 Failed2016-02-03
-1 Failed2016-02-01
-1 Failed2016-01-31
-1 Failed2016-01-29
-1 Failed2016-01-27
-1 Failed2016-01-25
-1 Failed2016-01-24
-1 Failed2016-01-22
-1 Failed2016-01-20
-1 Failed2016-01-18
-1 Failed2016-01-17
-1 Failed2016-01-15
-1 Failed2016-01-13
-1 Failed2016-01-11
-1 Failed2016-01-10
-1 Failed2016-01-08
-1 Failed2016-01-06
-1 Failed2016-01-04

Tags

Interaction and Network Protein
Homo sapiens Human immunodeficiency virus (HIV) Mus musculus Rattus norvegicus
protein-protein interaction SVM

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Zhang Zhang [2016-05-08]
    • Jian Sang [2016-04-04]
    • Lina Ma [2015-12-31]
    • Jian Sang [2015-12-07]
    • Jian Sang [2015-06-28]
    • Jian Sang [2015-06-27]
Stats