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Database Commons - CrossTope

CrossTope

Citations: 8

z-index 0.90

Short name CrossTope
Full name Structural Data Bank for Cross-Reactivity
Description The Structural Data Bank for Cross-Reactivity is a curate repository of three-dimensional structures of MHC: epitope complexes, focused on immunogenicity, similarity relationships and cross-reactivity prediction.
URL http://www.crosstope.com.br/
Year founded 2013
Last update & version NA    v1.0
Availability Free to all users
University/Institution hosted Federal University
Address 9500 Bento Gonalves Avenue,Bldg 43323,Rm 225,91501-970 Porto Alegre,RS,Brazil
City Porto Alegre
Province/State
Country/Region Brazil
Contact name Gustavo Fioravanti Vieira
Contact email gusfioravanti@yahoo.com.br
Data type(s)
Major organism(s)
Keyword(s)
  • cross-reactivity prediction
  • epitope complexes
  • MHC
Publication(s)
  • CrossTope: a curate repository of 3D structures of immunogenic peptide: MHC complexes. [PMID: 23396301]

    Marialva Sinigaglia, Dinler Amaral Antunes, Maurício Menegatti Rigo, José Artur Bogo Chies, Gustavo Fioravanti Vieira
    Database : the journal of biological databases and curation 2013:2013
    8 Citations (Google Scholar as of 2016-02-15)

    Abstract: The CrossTope is a highly curate repository of three-dimensional structures of peptide:major histocompatibility complex (MHC) class I complexes (pMHC-I). The complexes hosted by this databank were obtained in protein databases and by large-scale in silico construction of pMHC-I structures, using a new approach developed by our group. At this moment, the database contains 182 'non-redundant' pMHC-I complexes from two human and two murine alleles. A web server provides interface for database query. The user can download (i) structure coordinate files and (ii) topological and charges distribution maps images from the T-cell receptor-interacting surface of pMHC-I complexes. The retrieved structures and maps can be used to cluster similar epitopes in cross-reactivity approaches, to analyse viral escape mutations in a structural level or even to improve the immunogenicity of tumour antigens. Database URL: http://www.crosstope.com.br.

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Tags

Interaction and Network Protein Structure
Homo sapiens Mus musculus
cross-reactivity prediction epitope complexes MHC

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Lina Ma [2016-04-12]
    • Mengwei Li [2016-03-31]
    • Mengwei Li [2015-12-06]
    • Mengwei Li [2015-06-29]
    • Mengwei Li [2015-06-27]
Stats