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Database Commons - MelGene

MelGene

Citations: 4

z-index 0.69

Short name MelGene
Full name Field Synopsis of Genetic Association Studies in Cutaneous Melanoma
Description A Web-based database of genetic association studies in cutaneous melanoma enhanced with network-driven data exploration tools
URL http://bioserver-3.bioacademy.gr/Bioserver/MelGene/
Year founded 2014
Last update & version 2014-11-06    v2.0
Availability Free to all users
University/Institution hosted Academy of Athens
Address Soranou Ephessiou 4,115 27 Athens, GR,Greece
City Athens
Province/State
Country/Region Greece
Contact name George M. Spyrou
Contact email gspyrou@bioacademy.gr
Data type(s)
Major organism(s)
Keyword(s)
  • cutaneous melanoma
  • polymorphism
Publication(s)
  • A Web-based database of genetic association studies in cutaneous melanoma enhanced with network-driven data exploration tools. [PMID: 25380778]

    Emmanouil I Athanasiadis, Kyriaki Antonopoulou, Foteini Chatzinasiou, Christina M Lill, Marilena M Bourdakou, Argiris Sakellariou, Katerina Kypreou, Irene Stefanaki, Evangelos Evangelou, John P A Ioannidis, Lars Bertram, Alexander J Stratigos, George M Spyrou
    Database : the journal of biological databases and curation 2014:2014
    4 Citations (Google Scholar as of 2016-03-02)

    Abstract: The publicly available online database MelGene provides a comprehensive, regularly updated, collection of data from genetic association studies in cutaneous melanoma (CM), including random-effects meta-analysis results of all eligible polymorphisms. The updated database version includes data from 192 publications with information on 1114 significantly associated polymorphisms across 280 genes, along with new front-end and back-end capabilities. Various types of relationships between data are calculated and visualized as networks. We constructed 13 different networks containing the polymorphisms and the genes included in MelGene. We explored the derived network representations under the following questions: (i) are there nodes that deserve consideration regarding their network connectivity characteristics? (ii) What is the relation of either the genome-wide or nominally significant CM polymorphisms/genes with the ones highlighted by the network representation? We show that our network approach using the MelGene data reveals connections between statistically significant genes/ polymorphisms and other genes/polymorphisms acting as 'hubs' in the reconstructed networks. To the best of our knowledge, this is the first database containing data from a comprehensive field synopsis and systematic meta-analyses of genetic polymorphisms in CM that provides user-friendly tools for in-depth molecular network visualization and exploration. The proposed network connections highlight potentially new loci requiring further investigation of their relation to melanoma risk. Database URL: http://www.melgene.org. © The Author(s) 2014. Published by Oxford University Press.

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200 OK2016-02-19
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200 OK2016-02-15
200 OK2016-02-14
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200 OK2016-02-10
200 OK2016-02-08
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200 OK2016-02-03
200 OK2016-02-01
200 OK2016-01-31
200 OK2016-01-29
200 OK2016-01-27
200 OK2016-01-25
200 OK2016-01-24
200 OK2016-01-22
200 OK2016-01-20
200 OK2016-01-18
200 OK2016-01-17
200 OK2016-01-15
200 OK2016-01-13
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Tags

Disease DNA
Homo sapiens
cutaneous melanoma polymorphism

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Lin Liu [2016-03-27]
    • Li Yang [2015-06-26]
Stats