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Database Commons - TuberQ

TuberQ

Citations: 7

z-index 1.19

Short name TuberQ
Full name
Description a Mycobacterium tuberculosis protein druggability database
URL http://tuberq.proteinq.com.ar/bioflux/action/index/init.do
Year founded 2014
Last update & version NA    v1.0
Availability Not Available
University/Institution hosted Universidad de Buenos Aires
Address pabello _n II,Buenos Aires C1428EHA,Argentin
City Buenos Aires
Province/State
Country/Region Argentina
Contact name Adria _n G. Turjanski
Contact email adrian@qi.fcen.uba.ar
Data type(s)
Major organism(s)
Keyword(s)
  • anti-tb drugs
  • tuberculosis
Publication(s)
  • TuberQ: a Mycobacterium tuberculosis protein druggability database. [PMID: 24816183]

    Leandro Radusky, Lucas A Defelipe, Esteban Lanzarotti, Javier Luque, Xavier Barril, Marcelo A Marti, Adrián G Turjanski
    Database : the journal of biological databases and curation 2014:2014(0)
    7 Citations (Google Scholar as of 2016-04-28)

    Abstract: In 2012 an estimated 8.6 million people developed tuberculosis (TB) and 1.3 million died from the disease [including 320?000 deaths among human immunodeficiency virus (HIV)-positive people]. There is an urgent need for new anti-TB drugs owing to the following: the fact that current treatments have severe side effects, the increasing emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb), the negative drug-drug interactions with certain HIV (or other disease) treatments and the ineffectiveness against dormant Mtb. In this context we present here the TuberQ database, a novel resource for all researchers working in the field of drug development in TB. The main feature of TuberQ is to provide a druggability analysis of Mtb proteins in a consistent and effective manner, contributing to a better selection of potential drug targets for screening campaigns and the analysis of targets for structure-based drug design projects. The structural druggability analysis is combined with features related to the characteristics of putative inhibitor binding pockets and with functional and biological data of proteins. The structural analysis is performed on all available unique Mtb structures and high-quality structural homology-based models. This information is shown in an interactive manner, depicting the protein structure, the pockets and the associated characteristics for each protein. TuberQ also provides information about gene essentiality information, as determined from whole cell-based knockout experiments, and expression information obtained from microarray experiments done in different stress-related conditions. We hope that TuberQ will be a powerful tool for researchers working in TB and eventually will lead to the identification of novel putative targets and progresses in therapeutic activities. Database URL: http://tuberq.proteinq.com.ar/

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Tags

Disease
Homo sapiens
anti-tb drugs tuberculosis

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Guangyu Wang [2015-06-26]
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