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Database Commons - TSLP signaling pathway map

TSLP signaling pathway map

Citations: 10

z-index 2.30

Short name TSLP signaling pathway map
Full name Thymic stromal lymphopoietin signaling pathway map
Description TSLP signaling pathway map is a platform for analysis of TSLP-mediated signaling.
URL http://www.netpath.org/index.html
Year founded 2014
Last update & version NA    v1.0
Availability Free to all users
University/Institution hosted Johns Hopkins University
Address 733 N. Broadway,Baltimore,MD 21205,USA
City Baltimore
Province/State
Country/Region United States
Contact name Akhilesh Pandey
Contact email pandey@jhmi.edu
Data type(s)
Major organism(s)
Keyword(s)
  • thymic stromal lymphopoietin
Publication(s)
  • TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling. [PMID: 24573880]

    Jun Zhong, Jyoti Sharma, Rajesh Raju, Shyam Mohan Palapetta, T S Keshava Prasad, Tai-Chung Huang, Akinori Yoda, Jeffrey W Tyner, Diederik van Bodegom, David M Weinstock, Steven F Ziegler, Akhilesh Pandey
    Database : the journal of biological databases and curation 2014:2014
    10 Citations (Google Scholar as of 2016-04-28)

    Abstract: Thymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays a critical role in the regulation of immune responses and in the differentiation of hematopoietic cells. TSLP signals through a heterodimeric receptor complex consisting of an interleukin-7 receptor ? chain and a unique TSLP receptor (TSLPR) [also known as cytokine receptor-like factor 2 (CRLF2)]. Cellular targets of TSLP include dendritic cells, B cells, mast cells, regulatory T (Treg) cells and CD4+ and CD8+ T cells. The TSLP/TSLPR axis can activate multiple signaling transduction pathways including the JAK/STAT pathway and the PI-3 kinase pathway. Aberrant TSLP/TSLPR signaling has been associated with a variety of human diseases including asthma, atopic dermatitis, nasal polyposis, inflammatory bowel disease, eosinophilic eosophagitis and, most recently, acute lymphoblastic leukemia. A centralized resource of the TSLP signaling pathway cataloging signaling events is not yet available. In this study, we present a literature-annotated resource of reactions in the TSLP signaling pathway. This pathway map is publicly available through NetPath (http://www.netpath.org/), an open access signal transduction pathway resource developed previously by our group. This map includes 236 molecules and 252 reactions that are involved in TSLP/TSLPR signaling pathway. We expect that the TSLP signaling pathway map will provide a rich resource to study the biology of this important cytokine as well as to identify novel therapeutic targets for diseases associated with dysregulated TSLP/TSLPR signaling. Database URL: http://www.netpath.org/pathways?path_id=NetPath_24.

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Rate of accessibility:
HTTP status codeDate requested
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200 OK2017-12-29
200 OK2017-12-26
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200 OK2017-12-15
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200 OK2017-12-08
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200 OK2017-12-01
200 OK2017-11-28
200 OK2017-11-24
200 OK2017-11-21
200 OK2017-11-17
200 OK2017-11-14
200 OK2017-11-10
200 OK2017-11-07
200 OK2017-11-03
200 OK2017-10-31
200 OK2017-10-27
200 OK2017-10-24
200 OK2017-10-20
200 OK2017-10-17
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200 OK2017-10-10
200 OK2017-10-06
200 OK2017-10-03
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200 OK2017-09-22
200 OK2017-09-19
200 OK2017-09-15
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200 OK2017-09-08
200 OK2017-09-05
200 OK2017-09-01
200 OK2017-08-29
200 OK2017-08-25
200 OK2017-08-22
200 OK2017-08-18
200 OK2017-08-15
200 OK2017-08-11
200 OK2017-08-08
200 OK2017-08-04
200 OK2017-08-01
200 OK2017-07-28
200 OK2017-07-25
200 OK2017-07-21
200 OK2017-07-18
200 OK2017-07-14
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200 OK2017-04-25
200 OK2017-04-21
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200 OK2017-03-14
200 OK2017-03-10
200 OK2017-03-07
200 OK2017-03-03
200 OK2017-02-28
200 OK2017-02-24
200 OK2017-02-21
200 OK2017-02-17
200 OK2017-02-14
200 OK2017-02-10
200 OK2017-02-07
200 OK2017-02-03
200 OK2017-01-31
200 OK2017-01-27
200 OK2017-01-24
200 OK2017-01-20
200 OK2017-01-17
200 OK2017-01-13
200 OK2017-01-10
200 OK2017-01-06
200 OK2017-01-03
200 OK2016-12-30
200 OK2016-12-27
200 OK2016-12-23
200 OK2016-12-20
200 OK2016-12-16
200 OK2016-12-13
200 OK2016-12-09
200 OK2016-12-06
200 OK2016-12-02
200 OK2016-11-29
200 OK2016-11-25
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200 OK2016-11-18
200 OK2016-11-15
200 OK2016-11-11
200 OK2016-11-08
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200 OK2016-10-28
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200 OK2016-10-21
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503 Failed2016-10-14
503 Failed2016-10-11
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200 OK2016-09-30
200 OK2016-09-27
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200 OK2016-09-20
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200 OK2016-09-13
200 OK2016-09-09
200 OK2016-09-06
200 OK2016-09-02
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200 OK2016-08-26
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200 OK2016-08-19
200 OK2016-08-16
200 OK2016-08-12
200 OK2016-08-09
200 OK2016-08-05
200 OK2016-08-02
200 OK2016-07-29
200 OK2016-07-26
200 OK2016-07-22
200 OK2016-07-19
200 OK2016-07-15
200 OK2016-07-12
200 OK2016-07-08
200 OK2016-07-05
200 OK2016-07-01
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200 OK2016-04-01
200 OK2016-03-29
200 OK2016-03-28
200 OK2016-03-25
200 OK2016-03-23
200 OK2016-03-21
200 OK2016-03-18
200 OK2016-03-16
200 OK2016-03-14
200 OK2016-03-11
200 OK2016-03-09
200 OK2016-03-07
200 OK2016-03-04
200 OK2016-03-02
200 OK2016-02-29
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200 OK2016-02-24
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200 OK2016-02-19
200 OK2016-02-17
200 OK2016-02-15
200 OK2016-02-14
200 OK2016-02-12
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200 OK2016-02-08
200 OK2016-02-07
200 OK2016-02-05
200 OK2016-02-03
200 OK2016-02-01
200 OK2016-01-31
200 OK2016-01-29
200 OK2016-01-27
200 OK2016-01-25
200 OK2016-01-24
200 OK2016-01-22
200 OK2016-01-20
200 OK2016-01-18
200 OK2016-01-17
200 OK2016-01-15
200 OK2016-01-13
200 OK2016-01-11
200 OK2016-01-10
200 OK2016-01-08
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200 OK2016-01-04

Tags

Interaction and Network
Homo sapiens
thymic stromal lymphopoietin

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Mengwei Li [2016-02-15]
    • Guangyu Wang [2015-06-26]
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