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Database Commons - miRIAD

miRIAD

Citations: 4

z-index 0.53

Short name miRIAD
Full name Intragenic MicroRNA Database
Description miRIAD is a web search tool designed to help users to access integrated information concerning intragenic microRNAs and their host genes.
URL http://www.bioinfo.mochsl.org.br/miriad
Year founded 2014
Last update & version 2014-10-06    
Availability Free to all users
University/Institution hosted Clinic of the University of Munich
Address Munich, Germany
City Munich
Province/State
Country/Region Germany
Contact name Pedro A. F. Galante
Contact email pgalante@mochsl.org.br
Data type(s)
Major organism(s)
Keyword(s)
  • intragenic microRNA
Publication(s)
  • miRIAD-integrating microRNA inter- and intragenic data. [PMID: 25288656]

    Ludwig Christian Hinske, Gustavo S França, Hugo A M Torres, Daniel T Ohara, Camila M Lopes-Ramos, Jens Heyn, Luiz F L Reis, Lucila Ohno-Machado, Simone Kreth, Pedro A F Galante
    Database : the journal of biological databases and curation 2014:2014
    4 Citations (Google Scholar as of 2016-04-28)

    Abstract: MicroRNAs (miRNAs) are a class of small (?22 nucleotides) non-coding RNAs that post-transcriptionally regulate gene expression by interacting with target mRNAs. A majority of miRNAs is located within intronic or exonic regions of protein-coding genes (host genes), and increasing evidence suggests a functional relationship between these miRNAs and their host genes. Here, we introduce miRIAD, a web-service to facilitate the analysis of genomic and structural features of intragenic miRNAs and their host genes for five species (human, rhesus monkey, mouse, chicken and opossum). miRIAD contains the genomic classification of all miRNAs (inter- and intragenic), as well as classification of all protein-coding genes into host or non-host genes (depending on whether they contain an intragenic miRNA or not). We collected and processed public data from several sources to provide a clear visualization of relevant knowledge related to intragenic miRNAs, such as host gene function, genomic context, names of and references to intragenic miRNAs, miRNA binding sites, clusters of intragenic miRNAs, miRNA and host gene expression across different tissues and expression correlation for intragenic miRNAs and their host genes. Protein-protein interaction data are also presented for functional network analysis of host genes. In summary, miRIAD was designed to help the research community to explore, in a user-friendly environment, intragenic miRNAs, their host genes and functional annotations with minimal effort, facilitating hypothesis generation and in-silico validations. Database URL: http://www.miriad-database.org. © The Author(s) 2014. Published by Oxford University Press.

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Tags

RNA
Didelphimorphia Gallus gallus Homo sapiens Macaca mulatta Mus musculus
intragenic microRNA

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Zhang Zhang [2016-05-08]
    • Lin Liu [2016-03-29]
    • Li Yang [2015-06-26]
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