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Database Commons - miRGate

miRGate

Citations: 3

z-index 0.87

Short name miRGate
Full name miRGate
Description miRGate is a curated database of human, mouse and rat miRNAs/mRNAs targets. It is designed to analyze miRNA and gene isoforms lists under a common and consistent space of annotations. Including all existing 3 UTR and the entirely known miRNAs.
URL http://mirgate.bioinfo.cnio.es/miRGate/
Year founded 2015
Last update & version 2015-04-06    V 1.0
Availability Free to all users
University/Institution hosted Spanish National Cancer Research Centre
Address Madrid, Spain
City Madrid
Province/State
Country/Region Spain
Contact name Eduardo Andrés-León
Contact email eleon-ibis@us.es
Data type(s)
Major organism(s)
Keyword(s)
  • miRNA-mRNA
Publication(s)
  • miRGate: a curated database of human, mouse and rat miRNA-mRNA targets. [PMID: 25858286]

    Eduardo Andrés-León, Daniel González Peña, Gonzalo Gómez-López, David G Pisano
    Database : the journal of biological databases and curation 2015:2015
    3 Citations (Google Scholar as of 2015-12-29)

    Abstract: MicroRNAs (miRNAs) are small non-coding elements involved in the post-transcriptional down-regulation of gene expression through base pairing with messenger RNAs (mRNAs). Through this mechanism, several miRNA-mRNA pairs have been described as critical in the regulation of multiple cellular processes, including early embryonic development and pathological conditions. Many of these pairs (such as miR-15?b/BCL2 in apoptosis or BART-6/BCL6 in diffuse large B-cell lymphomas) were experimentally discovered and/or computationally predicted. Available tools for target prediction are usually based on sequence matching, thermodynamics and conservation, among other approaches. Nevertheless, the main issue on miRNA-mRNA pair prediction is the little overlapping results among different prediction methods, or even with experimentally validated pairs lists, despite the fact that all rely on similar principles. To circumvent this problem, we have developed miRGate, a database containing novel computational predicted miRNA-mRNA pairs that are calculated using well-established algorithms. In addition, it includes an updated and complete dataset of sequences for both miRNA and mRNAs 3'-Untranslated region from human (including human viruses), mouse and rat, as well as experimentally validated data from four well-known databases. The underlying methodology of miRGate has been successfully applied to independent datasets providing predictions that were convincingly validated by functional assays. miRGate is an open resource available at http://mirgate.bioinfo.cnio.es. For programmatic access, we have provided a representational state transfer web service application programming interface that allows accessing the database at http://mirgate.bioinfo.cnio.es/API/ Database URL: http://mirgate.bioinfo.cnio.es © The Author(s) 2015. Published by Oxford University Press.

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-1 Failed2018-01-26
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200 OK2018-01-16
200 OK2018-01-12
200 OK2018-01-09
200 OK2018-01-05
200 OK2018-01-02
200 OK2017-12-29
200 OK2017-12-26
200 OK2017-12-22
200 OK2017-12-19
200 OK2017-12-15
200 OK2017-12-12
200 OK2017-12-08
200 OK2017-12-05
200 OK2017-12-01
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200 OK2017-11-10
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200 OK2016-12-13
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-1 Failed2016-07-15
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200 OK2016-01-15
200 OK2016-01-13
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Tags

RNA
Homo sapiens Mus musculus Rattus norvegicus
miRNA-mRNA

Record metadata

  • Created on: 2015-06-20
  • Curated by:
    • Lin Liu [2016-03-29]
    • Mengwei Li [2016-02-20]
    • Li Yang [2015-06-26]
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