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Database Commons - SyStemCell

SyStemCell

Citations: 6

z-index 0.58

Short name SyStemCell
Full name
Description The SyStemCell is a comprehensive database deposited with multiple levels of original qualitative and quantitative experiment information on stem cell researches, including DNA CpG Hydroxy/methylation, histone modification, transciptional factor regulation, transcript products, microRNA information, protein products, and phosphorylation proteins. All the experimental data are rigorously curated from peer-reviewed publications, then recompiled and cross-linked by Entrez Gene. It aims to provide a basic platform for users to cross reference multiple-level experimental data of stem cells
URL http://lifecenter.sgst.cn/SyStemCell/
Year founded 2012
Last update & version 2012-02-10    v1.2
Availability Free to all users
University/Institution hosted Shanghai Center for Bioinformation Technology
Address
City Shanghai
Province/State
Country/Region China
Contact name Lu Xie
Contact email gro.tibcs@uleix
Data type(s)
Major organism(s)
Keyword(s)
  • stem cell
Publication(s)
  • SyStemCell: a database populated with multiple levels of experimental data from stem cell differentiation research. [PMID: 22807998]

    Jian Yu, Xiaobin Xing, Lingyao Zeng, Jiehuan Sun, Wei Li, Han Sun, Ying He, Jing Li, Guoqing Zhang, Chuan Wang, Yixue Li, Lu Xie
    PloS one 2012:7(7)
    6 Citations (Google Scholar as of 2016-02-27)

    Abstract: Elucidation of the mechanisms of stem cell differentiation is of great scientific interest. Increasing evidence suggests that stem cell differentiation involves changes at multiple levels of biological regulation, which together orchestrate the complex differentiation process; many related studies have been performed to investigate the various levels of regulation. The resulting valuable data, however, remain scattered. Most of the current stem cell-relevant databases focus on a single level of regulation (mRNA expression) from limited stem cell types; thus, a unifying resource would be of great value to compile the multiple levels of research data available. Here we present a database for this purpose, SyStemCell, deposited with multi-level experimental data from stem cell research. The database currently covers seven levels of stem cell differentiation-associated regulatory mechanisms, including DNA CpG 5-hydroxymethylcytosine/methylation, histone modification, transcript products, microRNA-based regulation, protein products, phosphorylation proteins and transcription factor regulation, all of which have been curated from 285 peer-reviewed publications selected from PubMed. The database contains 43,434 genes, recorded as 942,221 gene entries, for four organisms (Homo sapiens, Mus musculus, Rattus norvegicus, and Macaca mulatta) and various stem cell sources (e.g., embryonic stem cells, neural stem cells and induced pluripotent stem cells). Data in SyStemCell can be queried by Entrez gene ID, symbol, alias, or browsed by specific stem cell type at each level of genetic regulation. An online analysis tool is integrated to assist researchers to mine potential relationships among different regulations, and the potential usage of the database is demonstrated by three case studies. SyStemCell is the first database to bridge multi-level experimental information of stem cell studies, which can become an important reference resource for stem cell researchers. The database is available at http://lifecenter.sgst.cn/SyStemCell/.

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Accessibility

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200 OK2016-02-17
200 OK2016-02-15
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200 OK2016-02-08
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200 OK2016-02-05
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200 OK2016-01-29
200 OK2016-01-27
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200 OK2016-01-24
200 OK2016-01-22
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200 OK2016-01-17
200 OK2016-01-15
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200 OK2016-01-04

Tags

DNA Modification Protein RNA
Homo sapiens Macaca mulatta Mus musculus Rattus norvegicus
stem cell

Record metadata

  • Created on: 2015-06-30
  • Curated by:
    • Lin Xia [2016-03-28]
Stats